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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH1
All Species:
27.27
Human Site:
S2489
Identified Species:
50
UniProt:
P46531
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46531
NP_060087.3
2555
272505
S2489
L
T
P
P
S
Q
H
S
Y
S
S
P
V
D
N
Chimpanzee
Pan troglodytes
XP_520371
2555
272693
S2489
L
T
P
P
S
Q
H
S
Y
S
S
P
V
D
N
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
S2405
A
E
R
T
P
S
H
S
G
H
L
Q
G
E
H
Dog
Lupus familis
XP_537795
2544
270793
S2477
L
T
P
P
S
Q
H
S
Y
S
S
S
P
A
D
Cat
Felis silvestris
Mouse
Mus musculus
Q01705
2531
271296
S2464
L
T
P
P
S
Q
H
S
Y
S
S
S
P
V
D
Rat
Rattus norvegicus
Q07008
2531
270981
S2464
L
T
P
P
S
Q
H
S
Y
S
S
S
P
V
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
N2402
R
T
P
S
H
N
G
N
L
Q
G
E
H
P
Y
Chicken
Gallus gallus
XP_415420
2590
279561
S2524
L
T
P
P
S
Q
H
S
Y
S
S
P
L
D
N
Frog
Xenopus laevis
P21783
2524
275106
S2458
L
T
P
P
S
Q
H
S
Y
S
S
P
M
D
N
Zebra Danio
Brachydanio rerio
P46530
2437
262289
H2373
F
L
T
P
P
S
Q
H
S
Y
S
N
P
M
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
P2632
A
F
Y
Q
Y
L
T
P
S
S
Q
H
S
G
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
T1366
P
Q
H
F
M
N
T
T
H
T
T
P
T
S
L
Sea Urchin
Strong. purpuratus
P10079
1064
112055
V1001
P
S
F
G
F
T
V
V
R
D
N
G
Q
S
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
53.1
89.5
N.A.
89.3
90.2
N.A.
51.3
79.6
74.3
67.7
N.A.
44.4
N.A.
20.5
21.6
Protein Similarity:
100
99.8
66.5
93.7
N.A.
93
94
N.A.
63.6
87.6
85.2
78.7
N.A.
58.6
N.A.
33.3
29.4
P-Site Identity:
100
100
13.3
73.3
N.A.
73.3
73.3
N.A.
13.3
93.3
93.3
13.3
N.A.
6.6
N.A.
6.6
0
P-Site Similarity:
100
100
26.6
80
N.A.
80
80
N.A.
20
100
100
20
N.A.
6.6
N.A.
33.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
8
0
0
0
31
31
% D
% Glu:
0
8
0
0
0
0
0
0
0
0
0
8
0
8
0
% E
% Phe:
8
8
8
8
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
0
8
0
8
0
8
8
8
8
8
% G
% His:
0
0
8
0
8
0
62
8
8
8
0
8
8
0
8
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
54
8
0
0
0
8
0
0
8
0
8
0
8
0
8
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
8
8
0
% M
% Asn:
0
0
0
0
0
16
0
8
0
0
8
8
0
0
31
% N
% Pro:
16
0
62
62
16
0
0
8
0
0
0
39
31
8
0
% P
% Gln:
0
8
0
8
0
54
8
0
0
8
8
8
8
0
0
% Q
% Arg:
8
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% R
% Ser:
0
8
0
8
54
16
0
62
16
62
62
24
8
16
0
% S
% Thr:
0
62
8
8
0
8
16
8
0
8
8
0
8
0
8
% T
% Val:
0
0
0
0
0
0
8
8
0
0
0
0
16
16
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
8
0
0
0
54
8
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _