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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NOTCH1 All Species: 24.85
Human Site: S2516 Identified Species: 45.56
UniProt: P46531 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P46531 NP_060087.3 2555 272505 S2516 F L T P S P E S P D Q W S S S
Chimpanzee Pan troglodytes XP_520371 2555 272693 S2516 F L T P S P E S P D Q W S S S
Rhesus Macaque Macaca mulatta XP_001114248 2471 265649 S2432 W S S S S P H S A S D W S D V
Dog Lupus familis XP_537795 2544 270793 E2504 P F L T P S P E S P D Q W S S
Cat Felis silvestris
Mouse Mus musculus Q01705 2531 271296 E2491 T F L T P S P E S P D Q W S S
Rat Rattus norvegicus Q07008 2531 270981 E2491 P F L T P S P E S P D Q W S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512292 2467 261963 S2429 S S S P H S A S D W S D V T T
Chicken Gallus gallus XP_415420 2590 279561 S2551 F L T P S P E S P D Q W S S S
Frog Xenopus laevis P21783 2524 275106 S2485 F L T P S P E S P D Q W S S S
Zebra Danio Brachydanio rerio P46530 2437 262289 S2400 F L T P S A G S P D Q W S S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07207 2703 288835 S2659 Y P T P S P E S P G H W S S S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P14585 1429 157097 Q1393 S S E A F Q P Q C G A F G N G
Sea Urchin Strong. purpuratus P10079 1064 112055 W1028 E E V L Y T T W I N T N M V S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 53.1 89.5 N.A. 89.3 90.2 N.A. 51.3 79.6 74.3 67.7 N.A. 44.4 N.A. 20.5 21.6
Protein Similarity: 100 99.8 66.5 93.7 N.A. 93 94 N.A. 63.6 87.6 85.2 78.7 N.A. 58.6 N.A. 33.3 29.4
P-Site Identity: 100 100 33.3 13.3 N.A. 13.3 13.3 N.A. 13.3 100 100 86.6 N.A. 73.3 N.A. 0 6.6
P-Site Similarity: 100 100 46.6 13.3 N.A. 13.3 13.3 N.A. 33.3 100 100 86.6 N.A. 80 N.A. 13.3 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 8 8 0 8 0 8 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 8 39 31 8 0 8 0 % D
% Glu: 8 8 8 0 0 0 39 24 0 0 0 0 0 0 0 % E
% Phe: 39 24 0 0 8 0 0 0 0 0 0 8 0 0 0 % F
% Gly: 0 0 0 0 0 0 8 0 0 16 0 0 8 0 8 % G
% His: 0 0 0 0 8 0 8 0 0 0 8 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 39 24 8 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 8 0 8 0 8 0 % N
% Pro: 16 8 0 54 24 47 31 0 47 24 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 8 0 8 0 0 39 24 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 16 24 16 8 54 31 0 62 24 8 8 0 54 70 77 % S
% Thr: 8 0 47 24 0 8 8 0 0 0 8 0 0 8 8 % T
% Val: 0 0 8 0 0 0 0 0 0 0 0 0 8 8 8 % V
% Trp: 8 0 0 0 0 0 0 8 0 8 0 54 24 0 0 % W
% Tyr: 8 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _