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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH1
All Species:
20.3
Human Site:
S2538
Identified Species:
37.22
UniProt:
P46531
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46531
NP_060087.3
2555
272505
S2538
D
W
S
E
G
V
S
S
P
P
T
S
M
Q
S
Chimpanzee
Pan troglodytes
XP_520371
2555
272693
S2538
D
W
S
E
G
V
S
S
P
P
T
S
M
Q
S
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
G2454
G
A
G
G
G
Q
R
G
P
G
T
H
M
S
E
Dog
Lupus familis
XP_537795
2544
270793
S2526
S
D
W
S
E
G
I
S
S
P
P
T
S
T
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q01705
2531
271296
S2513
S
D
W
S
E
G
I
S
S
P
P
T
T
M
P
Rat
Rattus norvegicus
Q07008
2531
270981
S2513
S
D
W
S
E
G
I
S
S
P
P
T
S
M
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
G2451
A
N
S
Q
R
G
P
G
A
R
G
A
E
P
P
Chicken
Gallus gallus
XP_415420
2590
279561
S2573
D
W
S
E
G
I
S
S
P
P
T
S
M
Q
S
Frog
Xenopus laevis
P21783
2524
275106
S2507
D
W
S
E
G
I
S
S
P
P
T
S
M
Q
P
Zebra Danio
Brachydanio rerio
P46530
2437
262289
S2422
D
W
S
E
G
I
S
S
P
P
T
S
M
Q
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
P2681
W
S
E
G
V
Q
S
P
A
A
N
N
L
Y
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
Q1415
S
T
S
Y
T
Q
M
Q
N
E
P
M
T
R
Y
Sea Urchin
Strong. purpuratus
P10079
1064
112055
K1050
S
N
M
V
G
Q
D
K
W
T
R
Y
E
Q
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
53.1
89.5
N.A.
89.3
90.2
N.A.
51.3
79.6
74.3
67.7
N.A.
44.4
N.A.
20.5
21.6
Protein Similarity:
100
99.8
66.5
93.7
N.A.
93
94
N.A.
63.6
87.6
85.2
78.7
N.A.
58.6
N.A.
33.3
29.4
P-Site Identity:
100
100
26.6
13.3
N.A.
13.3
13.3
N.A.
6.6
93.3
86.6
86.6
N.A.
6.6
N.A.
6.6
20
P-Site Similarity:
100
100
26.6
20
N.A.
20
20
N.A.
20
100
93.3
93.3
N.A.
20
N.A.
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
0
0
0
0
0
16
8
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
39
24
0
0
0
0
8
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
8
39
24
0
0
0
0
8
0
0
16
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
8
16
54
31
0
16
0
8
8
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
0
0
0
24
24
0
0
0
0
0
0
0
8
% I
% Lys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% L
% Met:
0
0
8
0
0
0
8
0
0
0
0
8
47
16
8
% M
% Asn:
0
16
0
0
0
0
0
0
8
0
8
8
0
0
0
% N
% Pro:
0
0
0
0
0
0
8
8
47
62
31
0
0
8
31
% P
% Gln:
0
0
0
8
0
31
0
8
0
0
0
0
0
47
8
% Q
% Arg:
0
0
0
0
8
0
8
0
0
8
8
0
0
8
0
% R
% Ser:
39
8
54
24
0
0
47
62
24
0
0
39
16
8
31
% S
% Thr:
0
8
0
0
8
0
0
0
0
8
47
24
16
8
0
% T
% Val:
0
0
0
8
8
16
0
0
0
0
0
0
0
0
0
% V
% Trp:
8
39
24
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
0
0
8
0
8
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _