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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH1
All Species:
19.7
Human Site:
T1820
Identified Species:
36.11
UniProt:
P46531
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46531
NP_060087.3
2555
272505
T1820
W
G
D
E
D
L
E
T
K
K
F
R
F
E
E
Chimpanzee
Pan troglodytes
XP_520371
2555
272693
T1820
W
G
D
E
D
L
E
T
K
K
F
R
F
E
E
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
P1766
V
D
D
E
G
P
Q
P
K
K
V
K
A
E
D
Dog
Lupus familis
XP_537795
2544
270793
A1789
W
G
D
E
D
L
E
A
K
K
F
R
F
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Q01705
2531
271296
T1810
W
G
D
E
D
L
E
T
K
K
F
R
F
E
E
Rat
Rattus norvegicus
Q07008
2531
270981
T1810
W
G
D
E
D
L
E
T
K
K
F
R
F
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
S1762
L
S
D
G
G
P
Q
S
K
R
V
K
T
E
D
Chicken
Gallus gallus
XP_415420
2590
279561
T1859
G
D
E
E
T
L
D
T
K
K
F
R
F
E
E
Frog
Xenopus laevis
P21783
2524
275106
N1815
G
D
E
E
T
L
E
N
K
R
F
R
F
E
E
Zebra Danio
Brachydanio rerio
P46530
2437
262289
H1755
S
R
K
R
K
R
E
H
G
Q
L
W
F
P
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
M1828
W
S
D
D
E
S
D
M
P
L
P
K
R
Q
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
V765
I
T
N
I
R
I
T
V
Q
M
D
P
K
E
F
Sea Urchin
Strong. purpuratus
P10079
1064
112055
H400
Q
P
G
Y
T
G
T
H
C
E
T
D
I
D
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
53.1
89.5
N.A.
89.3
90.2
N.A.
51.3
79.6
74.3
67.7
N.A.
44.4
N.A.
20.5
21.6
Protein Similarity:
100
99.8
66.5
93.7
N.A.
93
94
N.A.
63.6
87.6
85.2
78.7
N.A.
58.6
N.A.
33.3
29.4
P-Site Identity:
100
100
33.3
93.3
N.A.
100
100
N.A.
20
66.6
60
20
N.A.
13.3
N.A.
6.6
6.6
P-Site Similarity:
100
100
53.3
93.3
N.A.
100
100
N.A.
53.3
80
73.3
26.6
N.A.
46.6
N.A.
26.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
0
24
62
8
39
0
16
0
0
0
8
8
0
8
16
% D
% Glu:
0
0
16
62
8
0
54
0
0
8
0
0
0
77
70
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
54
0
62
0
8
% F
% Gly:
16
39
8
8
16
8
0
0
8
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
16
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
8
0
8
0
0
0
0
0
0
8
0
0
% I
% Lys:
0
0
8
0
8
0
0
0
70
54
0
24
8
0
0
% K
% Leu:
8
0
0
0
0
54
0
0
0
8
8
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
8
0
8
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
0
% N
% Pro:
0
8
0
0
0
16
0
8
8
0
8
8
0
8
0
% P
% Gln:
8
0
0
0
0
0
16
0
8
8
0
0
0
8
0
% Q
% Arg:
0
8
0
8
8
8
0
0
0
16
0
54
8
0
8
% R
% Ser:
8
16
0
0
0
8
0
8
0
0
0
0
0
0
0
% S
% Thr:
0
8
0
0
24
0
16
39
0
0
8
0
8
0
0
% T
% Val:
8
0
0
0
0
0
0
8
0
0
16
0
0
0
0
% V
% Trp:
47
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _