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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NOTCH1 All Species: 11.52
Human Site: T2375 Identified Species: 21.11
UniProt: P46531 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P46531 NP_060087.3 2555 272505 T2375 L P S T R L A T Q P H L V Q T
Chimpanzee Pan troglodytes XP_520371 2555 272693 T2375 L P S T R L A T Q P H L V Q T
Rhesus Macaque Macaca mulatta XP_001114248 2471 265649 L2301 I T T P R E P L P P I V T F Q
Dog Lupus familis XP_537795 2544 270793 A2351 A L P N T R L A S Q P H L V Q
Cat Felis silvestris
Mouse Mus musculus Q01705 2531 271296 L2357 S P I I Y Q G L P N T R L A T
Rat Rattus norvegicus Q07008 2531 270981 L2357 S P I I Y Q G L P N T R L A T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512292 2467 261963 L2298 A T S S R E P L P P I V T F H
Chicken Gallus gallus XP_415420 2590 279561 S2407 M P S T R L A S Q P H L L Q N
Frog Xenopus laevis P21783 2524 275106 T2353 T T L S Q M M T Y Q A M P N T
Zebra Danio Brachydanio rerio P46530 2437 262289 W2260 A Q A G A C D W L Q R V Q Q Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07207 2703 288835 S2525 I M L A P P Q S S K N S A I M
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P14585 1429 157097 Q1262 E V V M Y L I Q Q G A S V E A
Sea Urchin Strong. purpuratus P10079 1064 112055 I897 Y A G Q N C E I D I N E C A S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 53.1 89.5 N.A. 89.3 90.2 N.A. 51.3 79.6 74.3 67.7 N.A. 44.4 N.A. 20.5 21.6
Protein Similarity: 100 99.8 66.5 93.7 N.A. 93 94 N.A. 63.6 87.6 85.2 78.7 N.A. 58.6 N.A. 33.3 29.4
P-Site Identity: 100 100 13.3 0 N.A. 13.3 13.3 N.A. 20 73.3 13.3 6.6 N.A. 0 N.A. 20 0
P-Site Similarity: 100 100 33.3 6.6 N.A. 20 20 N.A. 33.3 93.3 40 20 N.A. 20 N.A. 26.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 24 8 8 8 8 0 24 8 0 0 16 0 8 24 8 % A
% Cys: 0 0 0 0 0 16 0 0 0 0 0 0 8 0 0 % C
% Asp: 0 0 0 0 0 0 8 0 8 0 0 0 0 0 0 % D
% Glu: 8 0 0 0 0 16 8 0 0 0 0 8 0 8 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 16 0 % F
% Gly: 0 0 8 8 0 0 16 0 0 8 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 24 8 0 0 8 % H
% Ile: 16 0 16 16 0 0 8 8 0 8 16 0 0 8 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % K
% Leu: 16 8 16 0 0 31 8 31 8 0 0 24 31 0 0 % L
% Met: 8 8 0 8 0 8 8 0 0 0 0 8 0 0 8 % M
% Asn: 0 0 0 8 8 0 0 0 0 16 16 0 0 8 8 % N
% Pro: 0 39 8 8 8 8 16 0 31 39 8 0 8 0 0 % P
% Gln: 0 8 0 8 8 16 8 8 31 24 0 0 8 31 24 % Q
% Arg: 0 0 0 0 39 8 0 0 0 0 8 16 0 0 0 % R
% Ser: 16 0 31 16 0 0 0 16 16 0 0 16 0 0 8 % S
% Thr: 8 24 8 24 8 0 0 24 0 0 16 0 16 0 39 % T
% Val: 0 8 8 0 0 0 0 0 0 0 0 24 24 8 0 % V
% Trp: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 24 0 0 0 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _