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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH1
All Species:
14.24
Human Site:
T2497
Identified Species:
26.11
UniProt:
P46531
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46531
NP_060087.3
2555
272505
T2497
Y
S
S
P
V
D
N
T
P
S
H
Q
L
Q
V
Chimpanzee
Pan troglodytes
XP_520371
2555
272693
T2497
Y
S
S
P
V
D
N
T
P
S
H
Q
L
Q
V
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
P2413
G
H
L
Q
G
E
H
P
Y
L
T
P
S
P
E
Dog
Lupus familis
XP_537795
2544
270793
N2485
Y
S
S
S
P
A
D
N
T
P
S
H
Q
L
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q01705
2531
271296
N2472
Y
S
S
S
P
V
D
N
T
P
S
H
Q
L
Q
Rat
Rattus norvegicus
Q07008
2531
270981
N2472
Y
S
S
S
P
V
D
N
T
P
S
H
Q
L
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
L2410
L
Q
G
E
H
P
Y
L
T
P
S
P
E
S
P
Chicken
Gallus gallus
XP_415420
2590
279561
T2532
Y
S
S
P
L
D
N
T
P
S
H
Q
L
Q
V
Frog
Xenopus laevis
P21783
2524
275106
T2466
Y
S
S
P
M
D
N
T
P
S
H
Q
L
Q
V
Zebra Danio
Brachydanio rerio
P46530
2437
262289
N2381
S
Y
S
N
P
M
D
N
T
P
N
H
Q
Q
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
H2640
S
S
Q
H
S
G
G
H
T
P
Q
H
L
V
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
N1374
H
T
T
P
T
S
L
N
Y
L
S
P
E
Y
Q
Sea Urchin
Strong. purpuratus
P10079
1064
112055
T1009
R
D
N
G
Q
S
T
T
S
W
T
G
Q
C
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
53.1
89.5
N.A.
89.3
90.2
N.A.
51.3
79.6
74.3
67.7
N.A.
44.4
N.A.
20.5
21.6
Protein Similarity:
100
99.8
66.5
93.7
N.A.
93
94
N.A.
63.6
87.6
85.2
78.7
N.A.
58.6
N.A.
33.3
29.4
P-Site Identity:
100
100
0
20
N.A.
20
20
N.A.
0
93.3
93.3
20
N.A.
13.3
N.A.
6.6
6.6
P-Site Similarity:
100
100
13.3
26.6
N.A.
26.6
26.6
N.A.
0
100
100
33.3
N.A.
13.3
N.A.
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
8
0
0
0
31
31
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
8
0
8
0
0
0
0
0
0
16
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
8
8
8
8
8
0
0
0
0
8
0
0
0
% G
% His:
8
8
0
8
8
0
8
8
0
0
31
39
0
0
8
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
8
0
8
0
8
0
8
8
0
16
0
0
39
24
0
% L
% Met:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
8
0
0
31
39
0
0
8
0
0
0
0
% N
% Pro:
0
0
0
39
31
8
0
8
31
47
0
24
0
8
8
% P
% Gln:
0
8
8
8
8
0
0
0
0
0
8
31
39
39
39
% Q
% Arg:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
16
62
62
24
8
16
0
0
8
31
39
0
8
8
0
% S
% Thr:
0
8
8
0
8
0
8
39
47
0
16
0
0
0
0
% T
% Val:
0
0
0
0
16
16
0
0
0
0
0
0
0
8
39
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
54
8
0
0
0
0
8
0
16
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _