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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLCO1A2
All Species:
18.48
Human Site:
S421
Identified Species:
50.83
UniProt:
P46721
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46721
NP_066580.1
670
74145
S421
S
V
V
G
I
N
T
S
Y
E
G
I
P
Q
D
Chimpanzee
Pan troglodytes
XP_528756
670
74096
S421
S
V
V
G
I
N
T
S
Y
E
G
I
P
Q
D
Rhesus Macaque
Macaca mulatta
XP_001097798
670
74075
S421
S
V
V
G
I
N
T
S
Y
E
G
I
P
Q
D
Dog
Lupus familis
XP_852839
650
71613
T401
S
V
A
G
I
T
T
T
Y
K
G
I
Q
Q
D
Cat
Felis silvestris
Mouse
Mus musculus
Q9EP96
670
73946
S421
P
V
A
G
L
T
T
S
Y
E
G
V
Q
H
P
Rat
Rattus norvegicus
O88397
670
74558
S421
P
V
A
G
L
T
A
S
Y
E
G
V
H
H
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_416421
654
72192
W411
L
L
Y
F
S
A
F
W
T
I
C
D
T
S
P
Frog
Xenopus laevis
NP_001083171
649
71272
V409
S
I
N
F
S
V
F
V
M
G
C
K
N
S
P
Zebra Danio
Brachydanio rerio
NP_001038462
689
75417
S442
F
L
S
L
F
F
F
S
M
G
C
E
N
A
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
96.1
84.3
N.A.
72.8
72.5
N.A.
N.A.
57
47.1
45.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.2
98.2
90.9
N.A.
85.6
85.8
N.A.
N.A.
72
66.7
63.8
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
66.6
N.A.
46.6
40
N.A.
N.A.
0
6.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
80
N.A.
60
53.3
N.A.
N.A.
6.6
13.3
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
34
0
0
12
12
0
0
0
0
0
0
12
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
34
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
45
% D
% Glu:
0
0
0
0
0
0
0
0
0
56
0
12
0
0
0
% E
% Phe:
12
0
0
23
12
12
34
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
67
0
0
0
0
0
23
67
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
12
23
0
% H
% Ile:
0
12
0
0
45
0
0
0
0
12
0
45
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
12
0
12
0
0
0
% K
% Leu:
12
23
0
12
23
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
23
0
0
0
0
0
0
% M
% Asn:
0
0
12
0
0
34
0
0
0
0
0
0
23
0
0
% N
% Pro:
23
0
0
0
0
0
0
0
0
0
0
0
34
0
45
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
23
45
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
56
0
12
0
23
0
0
67
0
0
0
0
0
23
12
% S
% Thr:
0
0
0
0
0
34
56
12
12
0
0
0
12
0
0
% T
% Val:
0
67
34
0
0
12
0
12
0
0
0
23
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% W
% Tyr:
0
0
12
0
0
0
0
0
67
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _