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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEDD4
All Species:
3.94
Human Site:
S408
Identified Species:
7.22
UniProt:
P46934
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46934
NP_006145.2
1319
149059
S408
M
S
E
I
K
L
N
S
D
S
E
Y
I
K
L
Chimpanzee
Pan troglodytes
XP_523083
895
103693
R94
F
D
E
N
R
L
T
R
D
D
F
L
G
Q
V
Rhesus Macaque
Macaca mulatta
XP_001088005
1077
123165
R276
F
D
E
N
R
L
T
R
D
D
F
L
G
Q
V
Dog
Lupus familis
XP_851423
1251
141207
S408
M
S
E
I
K
L
N
S
H
S
E
C
I
K
L
Cat
Felis silvestris
Mouse
Mus musculus
P46935
887
102688
A86
V
V
R
V
K
V
I
A
G
I
G
L
A
K
K
Rat
Rattus norvegicus
Q62940
887
102376
G86
V
K
V
I
A
G
I
G
L
A
K
K
D
I
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511197
1255
141275
L410
K
P
L
E
E
L
K
L
N
S
G
G
K
H
P
Chicken
Gallus gallus
XP_424462
1045
119140
G243
Q
R
D
E
S
E
H
G
W
D
V
V
D
S
S
Frog
Xenopus laevis
Q2TAS2
751
86306
Zebra Danio
Brachydanio rerio
A9JRZ0
765
87445
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VVI3
1007
114856
E206
I
Y
H
A
F
I
R
E
T
R
E
Q
S
E
P
Honey Bee
Apis mellifera
XP_395191
782
90150
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39940
809
91798
K8
M
P
S
S
I
S
V
K
L
V
A
A
E
S
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
65.1
67.5
86.5
N.A.
56.4
56
N.A.
70
40.6
27.6
28.2
N.A.
35.9
36.2
N.A.
N.A.
Protein Similarity:
100
67.2
72.4
89.8
N.A.
60.9
61.1
N.A.
80
53.7
40.1
39.7
N.A.
49.7
46.5
N.A.
N.A.
P-Site Identity:
100
20
20
86.6
N.A.
13.3
13.3
N.A.
13.3
0
0
0
N.A.
6.6
0
N.A.
N.A.
P-Site Similarity:
100
40
40
86.6
N.A.
40
33.3
N.A.
26.6
13.3
0
0
N.A.
26.6
0
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
30.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
8
0
0
8
0
8
8
8
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
0
16
8
0
0
0
0
0
24
24
0
0
16
0
0
% D
% Glu:
0
0
31
16
8
8
0
8
0
0
24
0
8
8
0
% E
% Phe:
16
0
0
0
8
0
0
0
0
0
16
0
0
0
0
% F
% Gly:
0
0
0
0
0
8
0
16
8
0
16
8
16
0
0
% G
% His:
0
0
8
0
0
0
8
0
8
0
0
0
0
8
0
% H
% Ile:
8
0
0
24
8
8
16
0
0
8
0
0
16
8
0
% I
% Lys:
8
8
0
0
24
0
8
8
0
0
8
8
8
24
8
% K
% Leu:
0
0
8
0
0
39
0
8
16
0
0
24
0
0
31
% L
% Met:
24
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
16
0
0
16
0
8
0
0
0
0
0
0
% N
% Pro:
0
16
0
0
0
0
0
0
0
0
0
0
0
0
16
% P
% Gln:
8
0
0
0
0
0
0
0
0
0
0
8
0
16
0
% Q
% Arg:
0
8
8
0
16
0
8
16
0
8
0
0
0
0
0
% R
% Ser:
0
16
8
8
8
8
0
16
0
24
0
0
8
16
8
% S
% Thr:
0
0
0
0
0
0
16
0
8
0
0
0
0
0
0
% T
% Val:
16
8
8
8
0
8
8
0
0
8
8
8
0
0
16
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _