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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEDD4
All Species:
1.52
Human Site:
S490
Identified Species:
2.78
UniProt:
P46934
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46934
NP_006145.2
1319
149059
S490
Q
L
L
I
K
F
A
S
G
N
E
G
K
V
D
Chimpanzee
Pan troglodytes
XP_523083
895
103693
P173
G
W
V
V
L
D
Q
P
D
A
A
C
H
L
Q
Rhesus Macaque
Macaca mulatta
XP_001088005
1077
123165
P355
G
W
V
V
L
D
Q
P
D
A
A
C
H
L
Q
Dog
Lupus familis
XP_851423
1251
141207
P490
Q
L
L
I
K
F
A
P
G
N
E
D
K
V
D
Cat
Felis silvestris
Mouse
Mus musculus
P46935
887
102688
V165
R
D
D
F
L
G
Q
V
D
V
P
L
Y
P
L
Rat
Rattus norvegicus
Q62940
887
102376
P165
F
L
G
Q
V
D
V
P
L
Y
P
L
P
T
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511197
1255
141275
R497
Q
L
H
I
Q
F
A
R
G
N
E
G
K
V
S
Chicken
Gallus gallus
XP_424462
1045
119140
R322
A
H
R
R
F
R
S
R
R
H
I
S
E
D
L
Frog
Xenopus laevis
Q2TAS2
751
86306
F29
K
N
L
V
K
K
D
F
F
R
L
P
D
S
F
Zebra Danio
Brachydanio rerio
A9JRZ0
765
87445
G43
F
A
K
V
V
V
D
G
S
G
Q
C
H
S
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VVI3
1007
114856
S285
T
V
L
N
S
H
S
S
Q
S
T
D
D
Q
L
Honey Bee
Apis mellifera
XP_395191
782
90150
D60
D
L
N
T
I
S
G
D
Q
T
I
D
S
A
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39940
809
91798
V87
D
Q
G
F
L
G
V
V
N
V
R
V
G
D
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
65.1
67.5
86.5
N.A.
56.4
56
N.A.
70
40.6
27.6
28.2
N.A.
35.9
36.2
N.A.
N.A.
Protein Similarity:
100
67.2
72.4
89.8
N.A.
60.9
61.1
N.A.
80
53.7
40.1
39.7
N.A.
49.7
46.5
N.A.
N.A.
P-Site Identity:
100
0
0
86.6
N.A.
0
6.6
N.A.
73.3
0
13.3
0
N.A.
13.3
6.6
N.A.
N.A.
P-Site Similarity:
100
20
20
86.6
N.A.
6.6
13.3
N.A.
80
20
26.6
13.3
N.A.
33.3
6.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
30.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
0
0
0
24
0
0
16
16
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
24
0
0
0
% C
% Asp:
16
8
8
0
0
24
16
8
24
0
0
24
16
16
16
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
24
0
8
0
8
% E
% Phe:
16
0
0
16
8
24
0
8
8
0
0
0
0
0
8
% F
% Gly:
16
0
16
0
0
16
8
8
24
8
0
16
8
0
0
% G
% His:
0
8
8
0
0
8
0
0
0
8
0
0
24
0
0
% H
% Ile:
0
0
0
24
8
0
0
0
0
0
16
0
0
0
0
% I
% Lys:
8
0
8
0
24
8
0
0
0
0
0
0
24
0
0
% K
% Leu:
0
39
31
0
31
0
0
0
8
0
8
16
0
16
31
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
8
8
0
0
0
0
8
24
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
31
0
0
16
8
8
8
0
% P
% Gln:
24
8
0
8
8
0
24
0
16
0
8
0
0
8
16
% Q
% Arg:
8
0
8
8
0
8
0
16
8
8
8
0
0
0
0
% R
% Ser:
0
0
0
0
8
8
16
16
8
8
0
8
8
16
8
% S
% Thr:
8
0
0
8
0
0
0
0
0
8
8
0
0
8
8
% T
% Val:
0
8
16
31
16
8
16
16
0
16
0
8
0
24
8
% V
% Trp:
0
16
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _