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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEDD4
All Species:
4.85
Human Site:
S500
Identified Species:
8.89
UniProt:
P46934
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46934
NP_006145.2
1319
149059
S500
E
G
K
V
D
N
L
S
R
D
S
N
R
D
C
Chimpanzee
Pan troglodytes
XP_523083
895
103693
Q183
A
C
H
L
Q
Q
Q
Q
E
P
S
P
L
P
P
Rhesus Macaque
Macaca mulatta
XP_001088005
1077
123165
Q365
A
C
H
L
Q
Q
Q
Q
E
P
S
P
L
P
P
Dog
Lupus familis
XP_851423
1251
141207
S500
E
D
K
V
D
N
L
S
R
D
S
N
R
D
F
Cat
Felis silvestris
Mouse
Mus musculus
P46935
887
102688
E175
P
L
Y
P
L
P
T
E
N
P
R
M
E
R
P
Rat
Rattus norvegicus
Q62940
887
102376
R175
P
L
P
T
E
N
P
R
M
E
R
P
Y
T
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511197
1255
141275
Q507
E
G
K
V
S
N
L
Q
K
E
S
K
R
Y
C
Chicken
Gallus gallus
XP_424462
1045
119140
E332
I
S
E
D
L
E
P
E
P
L
E
T
G
D
I
Frog
Xenopus laevis
Q2TAS2
751
86306
V39
L
P
D
S
F
A
K
V
V
V
D
G
S
G
Q
Zebra Danio
Brachydanio rerio
A9JRZ0
765
87445
V53
Q
C
H
S
T
D
T
V
R
N
T
L
D
P
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VVI3
1007
114856
D295
T
D
D
Q
L
A
S
D
F
Q
R
R
F
H
I
Honey Bee
Apis mellifera
XP_395191
782
90150
T70
I
D
S
A
L
T
K
T
K
K
K
T
L
N
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39940
809
91798
H97
R
V
G
D
V
L
G
H
L
D
E
D
T
A
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
65.1
67.5
86.5
N.A.
56.4
56
N.A.
70
40.6
27.6
28.2
N.A.
35.9
36.2
N.A.
N.A.
Protein Similarity:
100
67.2
72.4
89.8
N.A.
60.9
61.1
N.A.
80
53.7
40.1
39.7
N.A.
49.7
46.5
N.A.
N.A.
P-Site Identity:
100
6.6
6.6
86.6
N.A.
0
6.6
N.A.
60
6.6
0
6.6
N.A.
0
0
N.A.
N.A.
P-Site Similarity:
100
13.3
13.3
86.6
N.A.
0
20
N.A.
73.3
13.3
0
33.3
N.A.
0
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
30.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
0
8
0
16
0
0
0
0
0
0
0
8
0
% A
% Cys:
0
24
0
0
0
0
0
0
0
0
0
0
0
0
16
% C
% Asp:
0
24
16
16
16
8
0
8
0
24
8
8
8
24
0
% D
% Glu:
24
0
8
0
8
8
0
16
16
16
16
0
8
0
0
% E
% Phe:
0
0
0
0
8
0
0
0
8
0
0
0
8
0
16
% F
% Gly:
0
16
8
0
0
0
8
0
0
0
0
8
8
8
0
% G
% His:
0
0
24
0
0
0
0
8
0
0
0
0
0
8
0
% H
% Ile:
16
0
0
0
0
0
0
0
0
0
0
0
0
0
16
% I
% Lys:
0
0
24
0
0
0
16
0
16
8
8
8
0
0
8
% K
% Leu:
8
16
0
16
31
8
24
0
8
8
0
8
24
0
0
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
8
0
0
0
% M
% Asn:
0
0
0
0
0
31
0
0
8
8
0
16
0
8
0
% N
% Pro:
16
8
8
8
0
8
16
0
8
24
0
24
0
24
31
% P
% Gln:
8
0
0
8
16
16
16
24
0
8
0
0
0
0
8
% Q
% Arg:
8
0
0
0
0
0
0
8
24
0
24
8
24
8
0
% R
% Ser:
0
8
8
16
8
0
8
16
0
0
39
0
8
0
0
% S
% Thr:
8
0
0
8
8
8
16
8
0
0
8
16
8
8
8
% T
% Val:
0
8
0
24
8
0
0
16
8
8
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
0
0
0
0
8
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _