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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEDD4
All Species:
2.12
Human Site:
S733
Identified Species:
3.89
UniProt:
P46934
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46934
NP_006145.2
1319
149059
S733
I
F
G
N
S
A
V
S
Q
P
A
S
S
S
N
Chimpanzee
Pan troglodytes
XP_523083
895
103693
Q395
S
Q
S
S
A
G
P
Q
S
Q
A
S
T
S
D
Rhesus Macaque
Macaca mulatta
XP_001088005
1077
123165
Q577
S
Q
S
S
A
G
P
Q
S
Q
A
S
T
S
D
Dog
Lupus familis
XP_851423
1251
141207
T725
V
D
H
N
S
R
T
T
T
W
T
K
P
V
V
Cat
Felis silvestris
Mouse
Mus musculus
P46935
887
102688
Q387
S
S
R
G
G
S
L
Q
T
C
I
F
E
E
Q
Rat
Rattus norvegicus
Q62940
887
102376
I387
G
G
S
S
Q
T
C
I
F
E
E
Q
P
T
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511197
1255
141275
R726
Y
Y
I
D
H
N
S
R
T
T
T
W
M
K
P
Chicken
Gallus gallus
XP_424462
1045
119140
L544
R
R
A
V
K
D
T
L
S
N
P
Q
S
P
Q
Frog
Xenopus laevis
Q2TAS2
751
86306
P251
R
T
H
L
H
T
P
P
D
L
P
E
G
Y
E
Zebra Danio
Brachydanio rerio
A9JRZ0
765
87445
G265
E
Q
R
T
T
Q
Q
G
Q
V
Y
F
L
H
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VVI3
1007
114856
R507
D
I
S
A
P
S
T
R
R
N
S
E
E
D
N
Honey Bee
Apis mellifera
XP_395191
782
90150
S282
S
G
P
G
S
R
R
S
S
E
Q
I
E
S
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39940
809
91798
I309
Q
V
G
G
G
S
N
I
P
P
V
N
G
A
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
65.1
67.5
86.5
N.A.
56.4
56
N.A.
70
40.6
27.6
28.2
N.A.
35.9
36.2
N.A.
N.A.
Protein Similarity:
100
67.2
72.4
89.8
N.A.
60.9
61.1
N.A.
80
53.7
40.1
39.7
N.A.
49.7
46.5
N.A.
N.A.
P-Site Identity:
100
20
20
13.3
N.A.
0
0
N.A.
0
6.6
0
6.6
N.A.
6.6
20
N.A.
N.A.
P-Site Similarity:
100
46.6
46.6
26.6
N.A.
13.3
13.3
N.A.
13.3
6.6
0
13.3
N.A.
26.6
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
30.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
16
8
0
0
0
0
24
0
0
8
8
% A
% Cys:
0
0
0
0
0
0
8
0
0
8
0
0
0
0
0
% C
% Asp:
8
8
0
8
0
8
0
0
8
0
0
0
0
8
16
% D
% Glu:
8
0
0
0
0
0
0
0
0
16
8
16
24
8
8
% E
% Phe:
0
8
0
0
0
0
0
0
8
0
0
16
0
0
0
% F
% Gly:
8
16
16
24
16
16
0
8
0
0
0
0
16
0
0
% G
% His:
0
0
16
0
16
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
8
8
8
0
0
0
0
16
0
0
8
8
0
0
0
% I
% Lys:
0
0
0
0
8
0
0
0
0
0
0
8
0
8
0
% K
% Leu:
0
0
0
8
0
0
8
8
0
8
0
0
8
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
0
0
16
0
8
8
0
0
16
0
8
0
0
16
% N
% Pro:
0
0
8
0
8
0
24
8
8
16
16
0
16
8
16
% P
% Gln:
8
24
0
0
8
8
8
24
16
16
8
16
0
0
16
% Q
% Arg:
16
8
16
0
0
16
8
16
8
0
0
0
0
0
0
% R
% Ser:
31
8
31
24
24
24
8
16
31
0
8
24
16
31
0
% S
% Thr:
0
8
0
8
8
16
24
8
24
8
16
0
16
8
8
% T
% Val:
8
8
0
8
0
0
8
0
0
8
8
0
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
0
% W
% Tyr:
8
8
0
0
0
0
0
0
0
0
8
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _