Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NEDD4 All Species: 1.82
Human Site: T887 Identified Species: 3.33
UniProt: P46934 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P46934 NP_006145.2 1319 149059 T887 R G K T S L D T S N D L G P L
Chimpanzee Pan troglodytes XP_523083 895 103693 I534 K L K K Q N D I P N K F E M K
Rhesus Macaque Macaca mulatta XP_001088005 1077 123165 I716 K L K K Q N D I P N K F E M K
Dog Lupus familis XP_851423 1251 141207 S870 T G P A V P Y S R D Y K R K Y
Cat Felis silvestris
Mouse Mus musculus P46935 887 102688 I526 K L K K Q T D I P N K F E M K
Rat Rattus norvegicus Q62940 887 102376 P526 L K K Q T D I P N K F E M K L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511197 1255 141275 S874 T G P A V P Y S R D Y K R K Y
Chicken Gallus gallus XP_424462 1045 119140 D683 K K L K K P A D I P N R F E M
Frog Xenopus laevis Q2TAS2 751 86306 Q390 R Q E L S Q Q Q P Q A G H C R
Zebra Danio Brachydanio rerio A9JRZ0 765 87445 Q404 R Q E L S Q Q Q P Q A G H C R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VVI3 1007 114856 V646 H I R K P T N V P N K F E I R
Honey Bee Apis mellifera XP_395191 782 90150 V421 Q L R K P N N V P N K F E I K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P39940 809 91798 L448 Y F R S Q P A L R I L P G Q C
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 65.1 67.5 86.5 N.A. 56.4 56 N.A. 70 40.6 27.6 28.2 N.A. 35.9 36.2 N.A. N.A.
Protein Similarity: 100 67.2 72.4 89.8 N.A. 60.9 61.1 N.A. 80 53.7 40.1 39.7 N.A. 49.7 46.5 N.A. N.A.
P-Site Identity: 100 20 20 6.6 N.A. 20 13.3 N.A. 6.6 0 13.3 13.3 N.A. 6.6 6.6 N.A. N.A.
P-Site Similarity: 100 26.6 26.6 20 N.A. 26.6 26.6 N.A. 20 20 20 20 N.A. 20 26.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 30.8 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 43.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 16 0 0 16 0 0 0 16 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 16 8 % C
% Asp: 0 0 0 0 0 8 31 8 0 16 8 0 0 0 0 % D
% Glu: 0 0 16 0 0 0 0 0 0 0 0 8 39 8 0 % E
% Phe: 0 8 0 0 0 0 0 0 0 0 8 39 8 0 0 % F
% Gly: 0 24 0 0 0 0 0 0 0 0 0 16 16 0 0 % G
% His: 8 0 0 0 0 0 0 0 0 0 0 0 16 0 0 % H
% Ile: 0 8 0 0 0 0 8 24 8 8 0 0 0 16 0 % I
% Lys: 31 16 39 47 8 0 0 0 0 8 39 16 0 24 31 % K
% Leu: 8 31 8 16 0 8 0 8 0 0 8 8 0 0 16 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 8 24 8 % M
% Asn: 0 0 0 0 0 24 16 0 8 47 8 0 0 0 0 % N
% Pro: 0 0 16 0 16 31 0 8 54 8 0 8 0 8 0 % P
% Gln: 8 16 0 8 31 16 16 16 0 16 0 0 0 8 0 % Q
% Arg: 24 0 24 0 0 0 0 0 24 0 0 8 16 0 24 % R
% Ser: 0 0 0 8 24 0 0 16 8 0 0 0 0 0 0 % S
% Thr: 16 0 0 8 8 16 0 8 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 16 0 0 16 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 16 0 0 0 16 0 0 0 16 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _