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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEDD4
All Species:
1.82
Human Site:
Y1100
Identified Species:
3.33
UniProt:
P46934
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.5
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46934
NP_006145.2
1319
149059
Y1100
M
E
S
V
D
S
E
Y
Y
N
S
L
R
W
I
Chimpanzee
Pan troglodytes
XP_523083
895
103693
K724
I
V
V
T
N
K
N
K
K
E
Y
I
Y
L
V
Rhesus Macaque
Macaca mulatta
XP_001088005
1077
123165
K906
I
V
V
T
N
K
N
K
K
E
Y
I
Y
L
V
Dog
Lupus familis
XP_851423
1251
141207
Q1063
E
L
F
G
Q
T
H
Q
H
E
L
K
I
G
G
Cat
Felis silvestris
Mouse
Mus musculus
P46935
887
102688
K716
I
V
V
T
N
K
N
K
K
E
Y
I
Y
L
V
Rat
Rattus norvegicus
Q62940
887
102376
K716
V
V
V
T
N
K
N
K
K
E
Y
I
Y
L
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511197
1255
141275
Q1067
E
L
F
G
Q
T
H
Q
H
E
L
K
A
D
G
Chicken
Gallus gallus
XP_424462
1045
119140
N873
E
I
M
V
T
N
E
N
K
R
E
Y
I
D
L
Frog
Xenopus laevis
Q2TAS2
751
86306
T580
S
I
P
V
T
E
D
T
K
K
E
Y
V
R
L
Zebra Danio
Brachydanio rerio
A9JRZ0
765
87445
T594
S
I
P
V
T
Q
D
T
K
K
E
Y
V
R
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VVI3
1007
114856
K836
I
D
V
T
N
E
N
K
D
E
Y
I
K
L
V
Honey Bee
Apis mellifera
XP_395191
782
90150
K611
I
P
L
T
D
E
N
K
D
E
Y
I
A
L
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39940
809
91798
G638
R
N
I
E
V
T
D
G
N
K
K
E
Y
V
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
65.1
67.5
86.5
N.A.
56.4
56
N.A.
70
40.6
27.6
28.2
N.A.
35.9
36.2
N.A.
N.A.
Protein Similarity:
100
67.2
72.4
89.8
N.A.
60.9
61.1
N.A.
80
53.7
40.1
39.7
N.A.
49.7
46.5
N.A.
N.A.
P-Site Identity:
100
0
0
0
N.A.
0
0
N.A.
0
13.3
6.6
6.6
N.A.
0
6.6
N.A.
N.A.
P-Site Similarity:
100
26.6
26.6
13.3
N.A.
26.6
26.6
N.A.
13.3
26.6
20
20
N.A.
40
26.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
30.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
16
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
16
0
24
0
16
0
0
0
0
16
0
% D
% Glu:
24
8
0
8
0
24
16
0
0
62
24
8
0
0
8
% E
% Phe:
0
0
16
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
16
0
0
0
8
0
0
0
0
0
8
16
% G
% His:
0
0
0
0
0
0
16
0
16
0
0
0
0
0
0
% H
% Ile:
39
24
8
0
0
0
0
0
0
0
0
47
16
0
8
% I
% Lys:
0
0
0
0
0
31
0
47
54
24
8
16
8
0
0
% K
% Leu:
0
16
8
0
0
0
0
0
0
0
16
8
0
47
24
% L
% Met:
8
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
39
8
47
8
8
8
0
0
0
0
0
% N
% Pro:
0
8
16
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
16
8
0
16
0
0
0
0
0
0
0
% Q
% Arg:
8
0
0
0
0
0
0
0
0
8
0
0
8
16
0
% R
% Ser:
16
0
8
0
0
8
0
0
0
0
8
0
0
0
0
% S
% Thr:
0
0
0
47
24
24
0
16
0
0
0
0
0
0
0
% T
% Val:
8
31
39
31
8
0
0
0
0
0
0
0
16
8
47
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
0
0
0
0
0
8
8
0
47
24
39
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _