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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEDD4
All Species:
0.91
Human Site:
Y562
Identified Species:
1.67
UniProt:
P46934
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46934
NP_006145.2
1319
149059
Y562
H
K
S
R
V
K
G
Y
L
R
L
K
M
T
Y
Chimpanzee
Pan troglodytes
XP_523083
895
103693
I245
A
F
T
T
R
R
Q
I
S
E
E
T
E
S
V
Rhesus Macaque
Macaca mulatta
XP_001088005
1077
123165
I427
A
F
T
T
R
R
Q
I
S
E
E
T
E
S
V
Dog
Lupus familis
XP_851423
1251
141207
N562
L
G
R
T
Y
Y
V
N
H
E
S
R
R
T
Q
Cat
Felis silvestris
Mouse
Mus musculus
P46935
887
102688
D237
W
V
V
L
D
Q
P
D
A
A
T
H
L
P
H
Rat
Rattus norvegicus
Q62940
887
102376
T237
L
D
Q
P
D
A
A
T
H
L
Q
H
P
P
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511197
1255
141275
R569
Y
Y
V
N
H
E
S
R
R
T
Q
W
K
R
P
Chicken
Gallus gallus
XP_424462
1045
119140
E394
I
T
P
D
S
N
G
E
Q
L
S
S
L
I
Q
Frog
Xenopus laevis
Q2TAS2
751
86306
S101
L
G
C
V
R
L
L
S
N
A
I
N
R
L
K
Zebra Danio
Brachydanio rerio
A9JRZ0
765
87445
L115
K
D
T
G
Y
Q
R
L
D
L
N
K
L
G
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VVI3
1007
114856
I357
N
N
G
I
L
A
Q
I
A
M
Q
Y
R
A
E
Honey Bee
Apis mellifera
XP_395191
782
90150
R132
E
G
R
T
I
P
V
R
R
Y
V
L
R
P
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39940
809
91798
T159
T
A
S
S
S
T
N
T
S
S
T
T
R
T
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
65.1
67.5
86.5
N.A.
56.4
56
N.A.
70
40.6
27.6
28.2
N.A.
35.9
36.2
N.A.
N.A.
Protein Similarity:
100
67.2
72.4
89.8
N.A.
60.9
61.1
N.A.
80
53.7
40.1
39.7
N.A.
49.7
46.5
N.A.
N.A.
P-Site Identity:
100
0
0
6.6
N.A.
0
0
N.A.
0
6.6
0
6.6
N.A.
0
0
N.A.
N.A.
P-Site Similarity:
100
20
20
13.3
N.A.
20
0
N.A.
13.3
13.3
6.6
26.6
N.A.
13.3
13.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
30.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
8
0
0
0
16
8
0
16
16
0
0
0
8
0
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
16
0
8
16
0
0
8
8
0
0
0
0
0
0
% D
% Glu:
8
0
0
0
0
8
0
8
0
24
16
0
16
0
16
% E
% Phe:
0
16
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
24
8
8
0
0
16
0
0
0
0
0
0
8
0
% G
% His:
8
0
0
0
8
0
0
0
16
0
0
16
0
0
8
% H
% Ile:
8
0
0
8
8
0
0
24
0
0
8
0
0
8
0
% I
% Lys:
8
8
0
0
0
8
0
0
0
0
0
16
8
0
8
% K
% Leu:
24
0
0
8
8
8
8
8
8
24
8
8
24
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
0
% M
% Asn:
8
8
0
8
0
8
8
8
8
0
8
8
0
0
8
% N
% Pro:
0
0
8
8
0
8
8
0
0
0
0
0
8
24
16
% P
% Gln:
0
0
8
0
0
16
24
0
8
0
24
0
0
0
16
% Q
% Arg:
0
0
16
8
24
16
8
16
16
8
0
8
39
8
8
% R
% Ser:
0
0
16
8
16
0
8
8
24
8
16
8
0
16
0
% S
% Thr:
8
8
24
31
0
8
0
16
0
8
16
24
0
24
0
% T
% Val:
0
8
16
8
8
0
16
0
0
0
8
0
0
0
16
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
8
8
0
0
16
8
0
8
0
8
0
8
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _