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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC6A8
All Species:
14.24
Human Site:
S222
Identified Species:
28.48
UniProt:
P48029
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48029
NP_001136277.1
635
70523
S222
E
N
K
V
L
R
L
S
G
G
L
E
V
P
G
Chimpanzee
Pan troglodytes
XP_529227
517
57747
A124
D
C
A
N
A
S
L
A
N
L
T
C
D
Q
L
Rhesus Macaque
Macaca mulatta
Q9MYX0
630
70239
T206
S
C
K
N
S
W
N
T
G
N
C
T
N
Y
F
Dog
Lupus familis
XP_549362
569
63441
C176
C
W
V
L
V
Y
F
C
V
W
K
G
V
K
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8VBW1
640
70981
S222
E
N
K
V
L
R
L
S
T
G
L
E
V
P
G
Rat
Rattus norvegicus
P28570
635
70613
S222
E
N
K
V
L
R
L
S
T
G
L
E
V
P
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521283
733
81919
E324
L
S
L
S
S
G
I
E
D
L
G
I
L
K
W
Chicken
Gallus gallus
NP_001025771
631
71046
E211
L
S
L
S
S
G
I
E
D
I
G
I
I
K
W
Frog
Xenopus laevis
A7Y2W8
633
71004
F206
I
S
E
D
I
G
D
F
G
E
V
Q
L
P
L
Zebra Danio
Brachydanio rerio
XP_695932
652
73002
S239
E
N
K
V
L
N
I
S
D
G
L
D
E
P
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P51905
622
69307
T208
T
E
N
C
M
Q
V
T
S
E
N
F
T
E
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q03614
615
69247
I220
N
A
P
N
S
H
V
I
R
S
V
T
D
L
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
80.7
40.3
83.1
N.A.
98.1
98.4
N.A.
49.2
52.9
40.1
73.7
N.A.
41.7
N.A.
40.4
N.A.
Protein Similarity:
100
80.9
61
84.7
N.A.
98.2
98.7
N.A.
62.8
68.8
61
83.4
N.A.
60
N.A.
59.3
N.A.
P-Site Identity:
100
6.6
13.3
6.6
N.A.
93.3
93.3
N.A.
0
0
13.3
66.6
N.A.
0
N.A.
6.6
N.A.
P-Site Similarity:
100
20
20
20
N.A.
93.3
93.3
N.A.
20
20
53.3
80
N.A.
26.6
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
9
0
9
0
0
9
0
0
0
0
0
0
0
% A
% Cys:
9
17
0
9
0
0
0
9
0
0
9
9
0
0
0
% C
% Asp:
9
0
0
9
0
0
9
0
25
0
0
9
17
0
0
% D
% Glu:
34
9
9
0
0
0
0
17
0
17
0
25
9
9
0
% E
% Phe:
0
0
0
0
0
0
9
9
0
0
0
9
0
0
9
% F
% Gly:
0
0
0
0
0
25
0
0
25
34
17
9
0
0
42
% G
% His:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% H
% Ile:
9
0
0
0
9
0
25
9
0
9
0
17
9
0
0
% I
% Lys:
0
0
42
0
0
0
0
0
0
0
9
0
0
25
0
% K
% Leu:
17
0
17
9
34
0
34
0
0
17
34
0
17
9
25
% L
% Met:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
9
34
9
25
0
9
9
0
9
9
9
0
9
0
0
% N
% Pro:
0
0
9
0
0
0
0
0
0
0
0
0
0
42
0
% P
% Gln:
0
0
0
0
0
9
0
0
0
0
0
9
0
9
0
% Q
% Arg:
0
0
0
0
0
25
0
0
9
0
0
0
0
0
0
% R
% Ser:
9
25
0
17
34
9
0
34
9
9
0
0
0
0
9
% S
% Thr:
9
0
0
0
0
0
0
17
17
0
9
17
9
0
0
% T
% Val:
0
0
9
34
9
0
17
0
9
0
17
0
34
0
0
% V
% Trp:
0
9
0
0
0
9
0
0
0
9
0
0
0
0
17
% W
% Tyr:
0
0
0
0
0
9
0
0
0
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _