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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ME1
All Species:
26.97
Human Site:
T19
Identified Species:
45.64
UniProt:
P48163
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48163
NP_002386.1
572
64150
T19
H
Q
R
G
Y
L
L
T
R
N
P
H
L
N
K
Chimpanzee
Pan troglodytes
XP_518610
768
84121
T197
H
Q
R
G
Y
L
L
T
R
N
P
H
L
N
K
Rhesus Macaque
Macaca mulatta
XP_001084781
572
63996
T19
H
Q
R
G
Y
L
L
T
R
N
P
H
L
N
K
Dog
Lupus familis
XP_532217
634
71129
W81
Y
F
W
K
Y
P
H
W
G
Q
I
C
N
T
Q
Cat
Felis silvestris
Mouse
Mus musculus
P06801
572
63980
T19
H
Q
R
G
Y
L
L
T
R
D
P
H
L
N
K
Rat
Rattus norvegicus
P13697
572
63984
T19
H
Q
R
G
Y
L
L
T
R
D
P
H
L
N
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512855
562
62388
F20
N
S
N
R
G
M
A
F
T
L
E
E
R
Q
Q
Chicken
Gallus gallus
NP_989634
557
61982
T20
L
N
K
G
M
A
F
T
L
E
E
R
Q
Q
L
Frog
Xenopus laevis
NP_001088519
613
67458
T63
K
K
R
G
Y
D
I
T
R
N
P
Y
L
N
K
Zebra Danio
Brachydanio rerio
NP_001082825
603
66722
T53
R
K
R
G
Y
D
I
T
R
N
P
H
L
N
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395280
537
59737
G16
R
Q
I
L
G
I
H
G
L
L
P
A
A
V
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780686
581
64710
L33
R
L
Q
G
L
K
A
L
R
L
P
Q
M
N
K
Poplar Tree
Populus trichocarpa
P34105
591
65205
L56
V
A
S
G
Y
T
L
L
R
D
P
H
H
N
K
Maize
Zea mays
P16243
636
69805
L101
V
A
S
G
Y
T
L
L
R
D
P
H
H
N
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74.3
95
82.6
N.A.
89.3
90.3
N.A.
79.3
75.8
68.8
68.4
N.A.
N.A.
57.6
N.A.
59.7
Protein Similarity:
100
74.4
97
86.5
N.A.
94.9
95.9
N.A.
89.3
88.4
80.5
82
N.A.
N.A.
73.4
N.A.
75.7
P-Site Identity:
100
100
100
6.6
N.A.
93.3
93.3
N.A.
0
13.3
66.6
73.3
N.A.
N.A.
20
N.A.
33.3
P-Site Similarity:
100
100
100
20
N.A.
100
100
N.A.
20
20
86.6
86.6
N.A.
N.A.
26.6
N.A.
46.6
Percent
Protein Identity:
48
44
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
65.4
61
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
53.3
53.3
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
60
60
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
15
0
0
0
8
15
0
0
0
0
8
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
0
0
0
0
0
15
0
0
0
29
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
8
15
8
0
0
0
% E
% Phe:
0
8
0
0
0
0
8
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
79
15
0
0
8
8
0
0
0
0
0
0
% G
% His:
36
0
0
0
0
0
15
0
0
0
0
58
15
0
0
% H
% Ile:
0
0
8
0
0
8
15
0
0
0
8
0
0
0
0
% I
% Lys:
8
15
8
8
0
8
0
0
0
0
0
0
0
0
79
% K
% Leu:
8
8
0
8
8
36
50
22
15
22
0
0
50
0
8
% L
% Met:
0
0
0
0
8
8
0
0
0
0
0
0
8
0
0
% M
% Asn:
8
8
8
0
0
0
0
0
0
36
0
0
8
72
0
% N
% Pro:
0
0
0
0
0
8
0
0
0
0
79
0
0
0
0
% P
% Gln:
0
43
8
0
0
0
0
0
0
8
0
8
8
15
15
% Q
% Arg:
22
0
50
8
0
0
0
0
72
0
0
8
8
0
0
% R
% Ser:
0
8
15
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
15
0
58
8
0
0
0
0
8
0
% T
% Val:
15
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% V
% Trp:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
72
0
0
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _