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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ME1
All Species:
40.91
Human Site:
T446
Identified Species:
69.23
UniProt:
P48163
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48163
NP_002386.1
572
64150
T446
V
T
L
P
N
G
Q
T
L
Y
P
G
Q
G
N
Chimpanzee
Pan troglodytes
XP_518610
768
84121
T642
V
T
L
P
N
G
Q
T
L
Y
P
G
Q
G
N
Rhesus Macaque
Macaca mulatta
XP_001084781
572
63996
T446
V
T
L
P
N
G
Q
T
L
Y
P
G
Q
G
N
Dog
Lupus familis
XP_532217
634
71129
T508
V
T
L
P
N
G
R
T
L
Y
P
G
Q
G
N
Cat
Felis silvestris
Mouse
Mus musculus
P06801
572
63980
T446
V
T
L
P
D
G
R
T
L
F
P
G
Q
G
N
Rat
Rattus norvegicus
P13697
572
63984
T446
V
T
L
P
D
G
R
T
L
F
P
G
Q
G
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512855
562
62388
T436
V
T
L
P
D
G
R
T
L
Y
P
G
Q
G
N
Chicken
Gallus gallus
NP_989634
557
61982
T435
V
T
L
P
N
G
K
T
L
Y
P
G
Q
G
N
Frog
Xenopus laevis
NP_001088519
613
67458
T490
V
T
L
A
N
G
Q
T
F
Y
P
G
Q
G
N
Zebra Danio
Brachydanio rerio
NP_001082825
603
66722
S480
V
T
L
A
D
G
R
S
F
Y
P
G
Q
G
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395280
537
59737
A396
A
E
C
T
A
E
Q
A
Y
I
A
T
K
G
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780686
581
64710
P457
P
F
D
P
F
T
L
P
N
G
K
T
L
I
P
Poplar Tree
Populus trichocarpa
P34105
591
65205
S450
L
A
L
S
N
P
T
S
Q
S
E
C
T
A
Q
Maize
Zea mays
P16243
636
69805
A504
S
E
C
T
A
E
Q
A
Y
T
W
S
Q
G
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74.3
95
82.6
N.A.
89.3
90.3
N.A.
79.3
75.8
68.8
68.4
N.A.
N.A.
57.6
N.A.
59.7
Protein Similarity:
100
74.4
97
86.5
N.A.
94.9
95.9
N.A.
89.3
88.4
80.5
82
N.A.
N.A.
73.4
N.A.
75.7
P-Site Identity:
100
100
100
93.3
N.A.
80
80
N.A.
86.6
93.3
86.6
66.6
N.A.
N.A.
13.3
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
86.6
86.6
N.A.
N.A.
20
N.A.
6.6
Percent
Protein Identity:
48
44
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
65.4
61
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
13.3
20
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
26.6
20
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
15
15
0
0
15
0
0
8
0
0
8
0
% A
% Cys:
0
0
15
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
0
0
8
0
29
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
15
0
0
0
15
0
0
0
0
8
0
0
0
0
% E
% Phe:
0
8
0
0
8
0
0
0
15
15
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
72
0
0
0
8
0
72
0
86
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% I
% Lys:
0
0
0
0
0
0
8
0
0
0
8
0
8
0
0
% K
% Leu:
8
0
79
0
0
0
8
0
58
0
0
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
50
0
0
0
8
0
0
0
0
0
72
% N
% Pro:
8
0
0
65
0
8
0
8
0
0
72
0
0
0
8
% P
% Gln:
0
0
0
0
0
0
43
0
8
0
0
0
79
0
8
% Q
% Arg:
0
0
0
0
0
0
36
0
0
0
0
0
0
0
15
% R
% Ser:
8
0
0
8
0
0
0
15
0
8
0
8
0
0
0
% S
% Thr:
0
72
0
15
0
8
8
65
0
8
0
15
8
0
0
% T
% Val:
72
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
15
58
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _