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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ME1
All Species:
37.58
Human Site:
Y72
Identified Species:
63.59
UniProt:
P48163
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48163
NP_002386.1
572
64150
Y72
L
N
S
D
F
D
R
Y
L
L
L
M
D
L
Q
Chimpanzee
Pan troglodytes
XP_518610
768
84121
Y250
L
N
S
D
F
D
R
Y
L
L
L
M
D
L
Q
Rhesus Macaque
Macaca mulatta
XP_001084781
572
63996
Y72
L
N
S
D
F
D
R
Y
L
L
L
M
D
L
Q
Dog
Lupus familis
XP_532217
634
71129
Y134
L
T
S
D
F
D
R
Y
L
L
L
M
D
L
Q
Cat
Felis silvestris
Mouse
Mus musculus
P06801
572
63980
Y72
L
N
S
D
F
D
R
Y
L
L
L
M
D
L
Q
Rat
Rattus norvegicus
P13697
572
63984
Y72
L
N
S
D
F
D
R
Y
L
L
L
M
D
L
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512855
562
62388
E73
M
G
L
Q
D
R
N
E
K
L
F
Y
K
V
L
Chicken
Gallus gallus
NP_989634
557
61982
E72
M
S
L
Q
D
R
N
E
K
L
F
Y
K
V
L
Frog
Xenopus laevis
NP_001088519
613
67458
Y116
K
S
S
D
L
D
K
Y
I
I
L
M
T
L
Q
Zebra Danio
Brachydanio rerio
NP_001082825
603
66722
Y106
R
S
N
P
L
D
K
Y
I
L
L
M
T
L
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395280
537
59737
N67
F
Y
R
L
L
E
Q
N
V
E
K
M
M
P
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780686
581
64710
Y85
D
H
S
P
L
D
K
Y
V
Q
L
M
D
L
Q
Poplar Tree
Populus trichocarpa
P34105
591
65205
Y109
Y
Q
L
P
L
Q
K
Y
T
A
M
M
E
L
E
Maize
Zea mays
P16243
636
69805
Y154
Y
Q
T
P
L
Q
R
Y
I
A
M
M
N
L
Q
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74.3
95
82.6
N.A.
89.3
90.3
N.A.
79.3
75.8
68.8
68.4
N.A.
N.A.
57.6
N.A.
59.7
Protein Similarity:
100
74.4
97
86.5
N.A.
94.9
95.9
N.A.
89.3
88.4
80.5
82
N.A.
N.A.
73.4
N.A.
75.7
P-Site Identity:
100
100
100
93.3
N.A.
100
100
N.A.
6.6
6.6
53.3
46.6
N.A.
N.A.
6.6
N.A.
53.3
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
20
26.6
80
73.3
N.A.
N.A.
26.6
N.A.
73.3
Percent
Protein Identity:
48
44
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
65.4
61
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
20
33.3
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
46.6
60
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
15
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
50
15
65
0
0
0
0
0
0
50
0
0
% D
% Glu:
0
0
0
0
0
8
0
15
0
8
0
0
8
0
8
% E
% Phe:
8
0
0
0
43
0
0
0
0
0
15
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
22
8
0
0
0
0
0
% I
% Lys:
8
0
0
0
0
0
29
0
15
0
8
0
15
0
0
% K
% Leu:
43
0
22
8
43
0
0
0
43
65
65
0
0
79
22
% L
% Met:
15
0
0
0
0
0
0
0
0
0
15
86
8
0
0
% M
% Asn:
0
36
8
0
0
0
15
8
0
0
0
0
8
0
0
% N
% Pro:
0
0
0
29
0
0
0
0
0
0
0
0
0
8
0
% P
% Gln:
0
15
0
15
0
15
8
0
0
8
0
0
0
0
72
% Q
% Arg:
8
0
8
0
0
15
50
0
0
0
0
0
0
0
0
% R
% Ser:
0
22
58
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
8
8
0
0
0
0
0
8
0
0
0
15
0
0
% T
% Val:
0
0
0
0
0
0
0
0
15
0
0
0
0
15
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
15
8
0
0
0
0
0
79
0
0
0
15
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _