KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LEPR
All Species:
12.42
Human Site:
S172
Identified Species:
34.17
UniProt:
P48357
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48357
NP_001003679.1
1165
132494
S172
L
P
E
V
L
E
D
S
P
L
V
P
Q
K
G
Chimpanzee
Pan troglodytes
XP_001161937
1165
132375
S172
L
P
E
V
L
E
D
S
P
L
V
P
P
K
G
Rhesus Macaque
Macaca mulatta
Q9MYL0
1163
132277
S170
L
P
E
V
L
E
D
S
P
L
V
P
Q
K
G
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P48356
1162
130770
S172
L
P
E
V
I
D
D
S
P
L
P
P
L
K
D
Rat
Rattus norvegicus
Q62959
1162
130814
L172
L
P
E
V
I
D
D
L
P
L
P
P
L
K
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512303
1113
123584
P152
Q
Q
K
N
R
S
L
P
G
D
G
L
E
E
K
Chicken
Gallus gallus
NP_989654
1148
129020
G162
A
V
S
E
L
S
L
G
D
A
S
T
S
S
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001106847
1091
122556
V131
V
S
P
H
Q
L
V
V
Q
M
D
V
H
S
D
Tiger Blowfish
Takifugu rubipres
NP_001124341
1116
124552
D155
D
S
E
E
A
A
S
D
P
P
V
F
C
E
A
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
95.6
N.A.
N.A.
75.3
75.6
N.A.
39.7
47.2
N.A.
25.9
26.1
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.2
97.1
N.A.
N.A.
85.3
85.8
N.A.
54.8
64.8
N.A.
43.6
43.4
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
100
N.A.
N.A.
66.6
60
N.A.
0
6.6
N.A.
0
20
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
93.3
100
N.A.
N.A.
80
73.3
N.A.
20
6.6
N.A.
13.3
26.6
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
0
0
0
12
12
0
0
0
12
0
0
0
0
12
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
0
% C
% Asp:
12
0
0
0
0
23
56
12
12
12
12
0
0
0
34
% D
% Glu:
0
0
67
23
0
34
0
0
0
0
0
0
12
23
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
12
12
0
12
0
0
0
34
% G
% His:
0
0
0
12
0
0
0
0
0
0
0
0
12
0
0
% H
% Ile:
0
0
0
0
23
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
12
0
0
0
0
0
0
0
0
0
0
56
12
% K
% Leu:
56
0
0
0
45
12
23
12
0
56
0
12
23
0
12
% L
% Met:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
0
% M
% Asn:
0
0
0
12
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
56
12
0
0
0
0
12
67
12
23
56
12
0
0
% P
% Gln:
12
12
0
0
12
0
0
0
12
0
0
0
23
0
0
% Q
% Arg:
0
0
0
0
12
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
23
12
0
0
23
12
45
0
0
12
0
12
23
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% T
% Val:
12
12
0
56
0
0
12
12
0
0
45
12
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _