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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LEPR
All Species:
9.09
Human Site:
T946
Identified Species:
25
UniProt:
P48357
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48357
NP_001003679.1
1165
132494
T946
V
V
S
L
L
S
T
T
D
L
E
K
G
S
V
Chimpanzee
Pan troglodytes
XP_001161937
1165
132375
T946
V
V
S
L
L
S
T
T
D
L
E
K
G
S
V
Rhesus Macaque
Macaca mulatta
Q9MYL0
1163
132277
T944
V
V
S
L
L
S
T
T
D
L
E
K
G
S
V
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P48356
1162
130770
P945
V
S
L
L
L
T
T
P
D
P
E
S
S
S
I
Rat
Rattus norvegicus
Q62959
1162
130814
P945
V
S
L
L
L
T
T
P
D
S
T
R
G
S
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512303
1113
123584
L901
Y
S
V
A
H
A
S
L
L
L
L
A
G
N
G
Chicken
Gallus gallus
NP_989654
1148
129020
P936
L
D
S
T
F
T
K
P
E
D
S
E
H
D
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001106847
1091
122556
P880
E
I
I
E
K
P
H
P
L
T
I
E
N
V
K
Tiger Blowfish
Takifugu rubipres
NP_001124341
1116
124552
G905
G
E
P
D
S
P
V
G
Q
A
W
P
E
E
S
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
95.6
N.A.
N.A.
75.3
75.6
N.A.
39.7
47.2
N.A.
25.9
26.1
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.2
97.1
N.A.
N.A.
85.3
85.8
N.A.
54.8
64.8
N.A.
43.6
43.4
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
N.A.
N.A.
46.6
46.6
N.A.
13.3
6.6
N.A.
0
0
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
N.A.
N.A.
60
66.6
N.A.
33.3
33.3
N.A.
13.3
0
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
12
0
12
0
0
0
12
0
12
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
12
0
12
0
0
0
0
56
12
0
0
0
12
0
% D
% Glu:
12
12
0
12
0
0
0
0
12
0
45
23
12
12
0
% E
% Phe:
0
0
0
0
12
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
12
0
0
0
0
0
0
12
0
0
0
0
56
0
12
% G
% His:
0
0
0
0
12
0
12
0
0
0
0
0
12
0
0
% H
% Ile:
0
12
12
0
0
0
0
0
0
0
12
0
0
0
23
% I
% Lys:
0
0
0
0
12
0
12
0
0
0
0
34
0
0
12
% K
% Leu:
12
0
23
56
56
0
0
12
23
45
12
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
12
12
0
% N
% Pro:
0
0
12
0
0
23
0
45
0
12
0
12
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
12
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% R
% Ser:
0
34
45
0
12
34
12
0
0
12
12
12
12
56
23
% S
% Thr:
0
0
0
12
0
34
56
34
0
12
12
0
0
0
0
% T
% Val:
56
34
12
0
0
0
12
0
0
0
0
0
0
12
34
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% W
% Tyr:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _