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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SOX9 All Species: 16.97
Human Site: S421 Identified Species: 37.33
UniProt: P48436 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P48436 NP_000337.1 509 56137 S421 S P Q Q I A Y S P F N L P H Y
Chimpanzee Pan troglodytes Q9BG89 509 56105 S421 S P Q Q I A Y S P F N L P H Y
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_538379 621 66196 I533 D Q P S T S Q I A Y T S L S L
Cat Felis silvestris
Mouse Mus musculus Q04887 507 56058 S419 S P Q Q I S Y S P F N L P H Y
Rat Rattus norvegicus O55170 466 50021 I378 D Q P S T S Q I A Y T S L S L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506094 508 56382 S421 S P Q Q I N Y S P F N L P H Y
Chicken Gallus gallus P48434 494 54924 G405 Q Q Q Q L G Y G S F N L Q H Y
Frog Xenopus laevis Q6DFF5 476 53301 S388 S P Q Q L N Y S S F N L Q H Y
Zebra Danio Brachydanio rerio Q6RVD7 245 26782 M158 F F D L G S K M T E L S P P S
Tiger Blowfish Takifugu rubipres NP_001072112 462 50618 G372 S P P H S D Y G S Y S S P A C
Fruit Fly Dros. melanogaster P40657 784 84853 N560 S M N E L S G N E Y L P S A N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 N.A. 47 N.A. 97 53.8 N.A. 88.2 82.9 80.1 22.3 48.5 20.6 N.A. N.A. N.A.
Protein Similarity: 100 99.8 N.A. 56.8 N.A. 97.6 64.6 N.A. 91.3 87 85.8 30.4 62.4 33.4 N.A. N.A. N.A.
P-Site Identity: 100 100 N.A. 0 N.A. 93.3 0 N.A. 93.3 53.3 73.3 6.6 26.6 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 N.A. 13.3 N.A. 100 13.3 N.A. 93.3 60 80 13.3 40 40 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 19 0 0 19 0 0 0 0 19 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % C
% Asp: 19 0 10 0 0 10 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 10 0 0 0 0 10 10 0 0 0 0 0 % E
% Phe: 10 10 0 0 0 0 0 0 0 55 0 0 0 0 0 % F
% Gly: 0 0 0 0 10 10 10 19 0 0 0 0 0 0 0 % G
% His: 0 0 0 10 0 0 0 0 0 0 0 0 0 55 0 % H
% Ile: 0 0 0 0 37 0 0 19 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 10 28 0 0 0 0 0 19 55 19 0 19 % L
% Met: 0 10 0 0 0 0 0 10 0 0 0 0 0 0 0 % M
% Asn: 0 0 10 0 0 19 0 10 0 0 55 0 0 0 10 % N
% Pro: 0 55 28 0 0 0 0 0 37 0 0 10 55 10 0 % P
% Gln: 10 28 55 55 0 0 19 0 0 0 0 0 19 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 64 0 0 19 10 46 0 46 28 0 10 37 10 19 10 % S
% Thr: 0 0 0 0 19 0 0 0 10 0 19 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 64 0 0 37 0 0 0 0 55 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _