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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LSS
All Species:
21.82
Human Site:
S270
Identified Species:
40
UniProt:
P48449
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48449
NP_001001438.1
732
83309
S270
L
Y
V
E
D
F
A
S
I
D
W
L
A
Q
R
Chimpanzee
Pan troglodytes
XP_001159379
732
83231
S270
L
Y
V
E
D
F
A
S
I
D
W
L
A
Q
R
Rhesus Macaque
Macaca mulatta
XP_001098607
732
83143
S270
L
Y
V
E
D
F
A
S
I
D
W
L
A
Q
R
Dog
Lupus familis
XP_548733
654
72679
F247
S
Q
V
W
D
T
S
F
A
V
Q
A
L
L
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8BLN5
733
83123
S271
L
Y
V
Q
D
Y
A
S
I
D
W
P
A
Q
R
Rat
Rattus norvegicus
P48450
733
83282
S271
L
Y
V
E
D
Y
A
S
I
D
W
P
A
Q
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514164
568
63937
G161
F
T
K
C
I
S
I
G
P
I
S
K
T
I
N
Chicken
Gallus gallus
NP_001006514
676
76923
V266
S
K
T
I
N
M
L
V
R
W
F
V
D
G
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001077036
735
83649
T271
L
Y
V
Q
D
Y
S
T
I
D
W
P
A
Q
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001193804
671
77348
F258
H
I
K
A
D
D
E
F
T
N
G
I
S
V
G
Poplar Tree
Populus trichocarpa
XP_002308131
761
86469
E297
L
F
T
V
P
Y
H
E
I
E
W
N
Q
A
R
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P38605
759
86015
E295
L
F
T
V
P
Y
H
E
V
N
W
N
E
A
R
Baker's Yeast
Sacchar. cerevisiae
P38604
731
83442
K272
I
Y
T
K
P
F
D
K
I
N
F
S
K
N
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.4
47.8
N.A.
85.5
84.3
N.A.
57.3
69.8
N.A.
75.2
N.A.
N.A.
N.A.
N.A.
46.3
Protein Similarity:
100
99.4
99
59.9
N.A.
92.5
91.6
N.A.
64.6
78.4
N.A.
86.1
N.A.
N.A.
N.A.
N.A.
62.7
P-Site Identity:
100
100
100
13.3
N.A.
80
80
N.A.
0
0
N.A.
66.6
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
20
N.A.
93.3
93.3
N.A.
0
20
N.A.
93.3
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
44.2
N.A.
N.A.
44.4
40.8
N.A.
Protein Similarity:
60.3
N.A.
N.A.
61.1
58
N.A.
P-Site Identity:
26.6
N.A.
N.A.
20
26.6
N.A.
P-Site Similarity:
46.6
N.A.
N.A.
46.6
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
39
0
8
0
0
8
47
16
0
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
62
8
8
0
0
47
0
0
8
0
0
% D
% Glu:
0
0
0
31
0
0
8
16
0
8
0
0
8
0
16
% E
% Phe:
8
16
0
0
0
31
0
16
0
0
16
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
8
0
0
8
0
0
8
8
% G
% His:
8
0
0
0
0
0
16
0
0
0
0
0
0
0
0
% H
% Ile:
8
8
0
8
8
0
8
0
62
8
0
8
0
8
0
% I
% Lys:
0
8
16
8
0
0
0
8
0
0
0
8
8
0
8
% K
% Leu:
62
0
0
0
0
0
8
0
0
0
0
24
8
8
0
% L
% Met:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
0
0
24
0
16
0
8
8
% N
% Pro:
0
0
0
0
24
0
0
0
8
0
0
24
0
0
0
% P
% Gln:
0
8
0
16
0
0
0
0
0
0
8
0
8
47
0
% Q
% Arg:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
62
% R
% Ser:
16
0
0
0
0
8
16
39
0
0
8
8
8
0
0
% S
% Thr:
0
8
31
0
0
8
0
8
8
0
0
0
8
0
0
% T
% Val:
0
0
54
16
0
0
0
8
8
8
0
8
0
8
0
% V
% Trp:
0
0
0
8
0
0
0
0
0
8
62
0
0
0
0
% W
% Tyr:
0
54
0
0
0
39
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _