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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LSS All Species: 18.48
Human Site: Y303 Identified Species: 33.89
UniProt: P48449 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P48449 NP_001001438.1 732 83309 Y303 V Y A L L N L Y E H H H S A H
Chimpanzee Pan troglodytes XP_001159379 732 83231 Y303 V Y A L L N L Y E H H H S A H
Rhesus Macaque Macaca mulatta XP_001098607 732 83143 Y303 V Y A L L N L Y E R H H S A H
Dog Lupus familis XP_548733 654 72679 S279 G V W A T W A S A S V A G L L
Cat Felis silvestris
Mouse Mus musculus Q8BLN5 733 83123 Y304 V Y G L L N L Y E R F H S T S
Rat Rattus norvegicus P48450 733 83282 Y304 V Y G L L N L Y E R F H S T S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514164 568 63937 Y193 H V S R I P D Y L W L G L D G
Chicken Gallus gallus NP_001006514 676 76923 M298 L G L D G M K M Q G T N G S Q
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001077036 735 83649 Y304 A Y F F L N V Y E A H H S T I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001193804 671 77348 H290 D S E A F K M H K D R L P D Y
Poplar Tree Populus trichocarpa XP_002308131 761 86469 V334 L D K A A E P V L M H W P G K
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P38605 759 86015 V332 L H K I V E P V L M R W P G A
Baker's Yeast Sacchar. cerevisiae P38604 731 83442 E306 N S L V V F Y E K Y L R N R F
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 97.4 47.8 N.A. 85.5 84.3 N.A. 57.3 69.8 N.A. 75.2 N.A. N.A. N.A. N.A. 46.3
Protein Similarity: 100 99.4 99 59.9 N.A. 92.5 91.6 N.A. 64.6 78.4 N.A. 86.1 N.A. N.A. N.A. N.A. 62.7
P-Site Identity: 100 100 93.3 0 N.A. 66.6 66.6 N.A. 6.6 0 N.A. 53.3 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 100 93.3 0 N.A. 66.6 66.6 N.A. 20 26.6 N.A. 60 N.A. N.A. N.A. N.A. 26.6
Percent
Protein Identity: 44.2 N.A. N.A. 44.4 40.8 N.A.
Protein Similarity: 60.3 N.A. N.A. 61.1 58 N.A.
P-Site Identity: 6.6 N.A. N.A. 0 0 N.A.
P-Site Similarity: 13.3 N.A. N.A. 26.6 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 24 24 8 0 8 0 8 8 0 8 0 24 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 8 0 8 0 0 8 0 0 8 0 0 0 16 0 % D
% Glu: 0 0 8 0 0 16 0 8 47 0 0 0 0 0 0 % E
% Phe: 0 0 8 8 8 8 0 0 0 0 16 0 0 0 8 % F
% Gly: 8 8 16 0 8 0 0 0 0 8 0 8 16 16 8 % G
% His: 8 8 0 0 0 0 0 8 0 16 39 47 0 0 24 % H
% Ile: 0 0 0 8 8 0 0 0 0 0 0 0 0 0 8 % I
% Lys: 0 0 16 0 0 8 8 0 16 0 0 0 0 0 8 % K
% Leu: 24 0 16 39 47 0 39 0 24 0 16 8 8 8 8 % L
% Met: 0 0 0 0 0 8 8 8 0 16 0 0 0 0 0 % M
% Asn: 8 0 0 0 0 47 0 0 0 0 0 8 8 0 0 % N
% Pro: 0 0 0 0 0 8 16 0 0 0 0 0 24 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 8 % Q
% Arg: 0 0 0 8 0 0 0 0 0 24 16 8 0 8 0 % R
% Ser: 0 16 8 0 0 0 0 8 0 8 0 0 47 8 16 % S
% Thr: 0 0 0 0 8 0 0 0 0 0 8 0 0 24 0 % T
% Val: 39 16 0 8 16 0 8 16 0 0 8 0 0 0 0 % V
% Trp: 0 0 8 0 0 8 0 0 0 8 0 16 0 0 0 % W
% Tyr: 0 47 0 0 0 0 8 54 0 8 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _