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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GCLC
All Species:
34.24
Human Site:
S133
Identified Species:
57.95
UniProt:
P48506
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48506
NP_001489.1
637
72766
S133
K
R
R
K
E
A
T
S
I
L
E
E
N
Q
A
Chimpanzee
Pan troglodytes
XP_001155809
637
72743
S133
K
R
R
K
E
A
T
S
I
L
E
E
N
Q
A
Rhesus Macaque
Macaca mulatta
XP_001108857
637
72671
S133
K
R
R
K
E
A
T
S
V
L
E
E
N
Q
A
Dog
Lupus familis
XP_852845
637
72820
S133
K
R
R
K
E
A
T
S
L
L
G
E
N
Q
A
Cat
Felis silvestris
Mouse
Mus musculus
P97494
637
72553
S133
K
R
R
K
E
A
T
S
V
L
G
E
H
Q
A
Rat
Rattus norvegicus
P19468
637
72601
S133
K
R
R
K
E
A
T
S
V
L
G
E
H
Q
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509228
587
66788
F125
G
A
S
K
S
L
F
F
P
D
E
A
I
N
K
Chicken
Gallus gallus
XP_419910
707
80027
S204
K
R
R
Q
E
A
A
S
V
L
K
E
N
E
A
Frog
Xenopus laevis
NP_001108242
637
72712
S133
K
R
R
Q
E
A
S
S
L
L
S
E
N
N
S
Zebra Danio
Brachydanio rerio
NP_954971
631
72397
S133
K
R
R
R
E
A
S
S
V
L
K
K
N
E
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W3K5
717
80727
E133
Y
R
R
E
E
V
T
E
L
L
A
K
D
E
C
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q20117
654
74350
K136
L
R
R
Q
V
V
K
K
L
L
K
K
D
E
T
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32477
678
78235
L133
R
A
I
A
E
Y
K
L
S
E
Y
A
R
Q
D
Red Bread Mold
Neurospora crassa
Q8X0X0
728
81861
D148
L
R
R
C
I
A
K
D
H
M
L
S
N
E
H
Conservation
Percent
Protein Identity:
100
99.8
99.3
97.1
N.A.
94.5
94.1
N.A.
85.4
78
85.2
81.6
N.A.
53.4
N.A.
53.3
N.A.
Protein Similarity:
100
99.8
99.5
98.4
N.A.
97.3
97.3
N.A.
88.6
82.3
91.6
89.8
N.A.
67.7
N.A.
69.8
N.A.
P-Site Identity:
100
100
93.3
86.6
N.A.
80
80
N.A.
13.3
66.6
60
53.3
N.A.
33.3
N.A.
20
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
13.3
93.3
86.6
93.3
N.A.
66.6
N.A.
60
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
41.4
44.3
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
59.4
62.2
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
26.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
40
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
15
0
8
0
72
8
0
0
0
8
15
0
0
50
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
0
0
0
0
0
0
0
8
0
8
0
0
15
0
8
% D
% Glu:
0
0
0
8
79
0
0
8
0
8
29
58
0
36
0
% E
% Phe:
0
0
0
0
0
0
8
8
0
0
0
0
0
0
0
% F
% Gly:
8
0
0
0
0
0
0
0
0
0
22
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
15
0
8
% H
% Ile:
0
0
8
0
8
0
0
0
15
0
0
0
8
0
0
% I
% Lys:
65
0
0
50
0
0
22
8
0
0
22
22
0
0
8
% K
% Leu:
15
0
0
0
0
8
0
8
29
79
8
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
58
15
0
% N
% Pro:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% P
% Gln:
0
0
0
22
0
0
0
0
0
0
0
0
0
50
0
% Q
% Arg:
8
86
86
8
0
0
0
0
0
0
0
0
8
0
0
% R
% Ser:
0
0
8
0
8
0
15
65
8
0
8
8
0
0
8
% S
% Thr:
0
0
0
0
0
0
50
0
0
0
0
0
0
0
15
% T
% Val:
0
0
0
0
8
15
0
0
36
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
8
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _