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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTDSS1 All Species: 35.45
Human Site: S283 Identified Species: 60
UniProt: P48651 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P48651 NP_055569.1 473 55528 S283 R W F D P K S S F Q R V A G V
Chimpanzee Pan troglodytes XP_001145729 327 38255 M148 V A G V Y L F M I I W Q L T E
Rhesus Macaque Macaca mulatta XP_001091545 473 55539 S283 R W F D P K S S F Q R V A G V
Dog Lupus familis XP_854779 507 59109 S317 R W F D P K S S F Q R V A G I
Cat Felis silvestris
Mouse Mus musculus Q99LH2 473 55585 S283 R W F D P K S S F Q R V A G I
Rat Rattus norvegicus NP_001012113 473 55645 S283 R W F D P K S S F Q R V A G I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505556 461 54262 S271 R W F D P K S S F Q R V A G I
Chicken Gallus gallus NP_001026676 473 55473 S283 R W F D P K S S F Q R V A G I
Frog Xenopus laevis NP_001090249 465 54716 S283 R W F D P K S S F Q R V A G I
Zebra Danio Brachydanio rerio NP_957250 465 54427 S283 R W L D P K S S L Q R V M G V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_649242 498 56816 G311 K D I S T T T G K I K R A M L
Honey Bee Apis mellifera XP_393811 477 54933 G282 L D I E S T T G K L K R A M L
Nematode Worm Caenorhab. elegans NP_509673 507 58724 K306 W E S I K H I K T N R G R F K
Sea Urchin Strong. purpuratus XP_001196273 245 28950 W66 D G I E H N I W R G L S H A S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 69.1 99.7 89.3 N.A. 97.2 97 N.A. 80.3 91.7 86 78 N.A. 48.1 48.4 41.4 30.4
Protein Similarity: 100 69.1 99.7 91.5 N.A. 99.3 98.9 N.A. 86.8 96.8 92.1 86.6 N.A. 65.2 66.6 58.7 39.7
P-Site Identity: 100 0 100 93.3 N.A. 93.3 93.3 N.A. 93.3 93.3 93.3 80 N.A. 6.6 6.6 6.6 0
P-Site Similarity: 100 0 100 100 N.A. 100 100 N.A. 100 100 100 80 N.A. 33.3 33.3 6.6 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 0 0 0 0 0 0 0 72 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 15 0 65 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 8 0 15 0 0 0 0 0 0 0 0 0 0 8 % E
% Phe: 0 0 58 0 0 0 8 0 58 0 0 0 0 8 0 % F
% Gly: 0 8 8 0 0 0 0 15 0 8 0 8 0 65 0 % G
% His: 0 0 0 0 8 8 0 0 0 0 0 0 8 0 0 % H
% Ile: 0 0 22 8 0 0 15 0 8 15 0 0 0 0 43 % I
% Lys: 8 0 0 0 8 65 0 8 15 0 15 0 0 0 8 % K
% Leu: 8 0 8 0 0 8 0 0 8 8 8 0 8 0 15 % L
% Met: 0 0 0 0 0 0 0 8 0 0 0 0 8 15 0 % M
% Asn: 0 0 0 0 0 8 0 0 0 8 0 0 0 0 0 % N
% Pro: 0 0 0 0 65 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 65 0 8 0 0 0 % Q
% Arg: 65 0 0 0 0 0 0 0 8 0 72 15 8 0 0 % R
% Ser: 0 0 8 8 8 0 65 65 0 0 0 8 0 0 8 % S
% Thr: 0 0 0 0 8 15 15 0 8 0 0 0 0 8 0 % T
% Val: 8 0 0 8 0 0 0 0 0 0 0 65 0 0 22 % V
% Trp: 8 65 0 0 0 0 0 8 0 0 8 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _