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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IDH2
All Species:
20.61
Human Site:
S17
Identified Species:
37.78
UniProt:
P48735
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48735
NP_002159.2
452
50909
S17
S
L
C
R
A
S
G
S
R
P
A
W
A
P
A
Chimpanzee
Pan troglodytes
XP_510589
452
50861
S17
S
L
C
R
A
S
G
S
R
P
A
W
A
P
A
Rhesus Macaque
Macaca mulatta
XP_001095686
452
50865
S17
S
L
C
R
A
S
G
S
R
P
A
W
A
P
A
Dog
Lupus familis
XP_536192
517
57031
A69
A
V
R
A
N
G
G
A
R
H
G
R
G
G
G
Cat
Felis silvestris
Mouse
Mus musculus
P54071
452
50888
S17
S
L
C
R
A
S
G
S
A
R
T
W
A
P
A
Rat
Rattus norvegicus
P56574
452
50949
S17
S
L
C
R
A
S
G
S
T
R
T
W
A
P
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507484
450
50551
R21
V
I
R
V
E
A
E
R
K
L
G
E
K
V
N
Chicken
Gallus gallus
NP_001026770
452
50451
L18
A
L
S
R
A
A
G
L
S
R
C
T
P
P
A
Frog
Xenopus laevis
NP_001080321
454
50741
T17
S
L
C
R
A
S
A
T
A
L
G
K
N
P
G
Zebra Danio
Brachydanio rerio
NP_955858
449
50378
T17
S
L
S
R
S
A
A
T
L
S
K
S
P
A
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_509875
435
49027
A17
V
L
L
A
R
N
V
A
T
A
A
T
Q
E
R
Sea Urchin
Strong. purpuratus
XP_001176537
449
50176
R17
R
A
F
V
A
A
T
R
T
D
S
P
R
C
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P41939
412
46544
E12
K
V
A
N
P
I
V
E
M
D
G
D
E
Q
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.5
79.8
N.A.
95.1
94.6
N.A.
82.5
88.7
86.5
84
N.A.
N.A.
N.A.
65.7
69.9
Protein Similarity:
100
99.7
99.5
83.9
N.A.
97.1
96.9
N.A.
86.7
93.5
92.2
92
N.A.
N.A.
N.A.
76.3
81.6
P-Site Identity:
100
100
100
13.3
N.A.
80
80
N.A.
0
40
46.6
20
N.A.
N.A.
N.A.
13.3
6.6
P-Site Similarity:
100
100
100
33.3
N.A.
80
80
N.A.
20
53.3
53.3
40
N.A.
N.A.
N.A.
26.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
58.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
71.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
8
8
16
62
31
16
16
16
8
31
0
39
8
47
% A
% Cys:
0
0
47
0
0
0
0
0
0
0
8
0
0
8
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
16
0
8
0
0
0
% D
% Glu:
0
0
0
0
8
0
8
8
0
0
0
8
8
8
0
% E
% Phe:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
8
54
0
0
0
31
0
8
8
16
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
8
0
0
0
8
0
0
0
0
0
0
0
0
0
% I
% Lys:
8
0
0
0
0
0
0
0
8
0
8
8
8
0
0
% K
% Leu:
0
70
8
0
0
0
0
8
8
16
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
8
8
0
0
0
0
0
0
8
0
8
% N
% Pro:
0
0
0
0
8
0
0
0
0
24
0
8
16
54
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% Q
% Arg:
8
0
16
62
8
0
0
16
31
24
0
8
8
0
8
% R
% Ser:
54
0
16
0
8
47
0
39
8
8
8
8
0
0
0
% S
% Thr:
0
0
0
0
0
0
8
16
24
0
16
16
0
0
8
% T
% Val:
16
16
0
16
0
0
16
0
0
0
0
0
0
8
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
39
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _