KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IDH2
All Species:
40.3
Human Site:
T197
Identified Species:
73.89
UniProt:
P48735
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48735
NP_002159.2
452
50909
T197
G
T
F
K
M
V
F
T
P
K
D
G
S
G
V
Chimpanzee
Pan troglodytes
XP_510589
452
50861
T197
G
T
F
K
M
V
F
T
P
K
D
G
S
G
V
Rhesus Macaque
Macaca mulatta
XP_001095686
452
50865
T197
G
T
F
K
M
V
F
T
P
K
D
G
S
G
V
Dog
Lupus familis
XP_536192
517
57031
S263
G
T
F
K
I
I
F
S
P
K
D
G
S
G
A
Cat
Felis silvestris
Mouse
Mus musculus
P54071
452
50888
T197
G
T
F
K
L
V
F
T
P
K
D
G
S
S
A
Rat
Rattus norvegicus
P56574
452
50949
T197
G
M
F
K
L
V
F
T
P
K
D
G
S
G
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507484
450
50551
T196
G
S
F
K
M
V
F
T
P
K
D
G
S
G
V
Chicken
Gallus gallus
NP_001026770
452
50451
T197
G
T
F
K
M
V
F
T
P
K
D
G
S
G
V
Frog
Xenopus laevis
NP_001080321
454
50741
T198
G
T
F
K
M
V
F
T
P
A
N
G
T
A
T
Zebra Danio
Brachydanio rerio
NP_955858
449
50378
T195
G
K
F
K
M
V
F
T
P
A
D
G
S
K
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_509875
435
49027
N180
S
T
L
Q
L
L
V
N
K
P
D
G
S
K
D
Sea Urchin
Strong. purpuratus
XP_001176537
449
50176
S197
G
K
F
E
L
V
F
S
P
A
S
G
A
E
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P41939
412
46544
E174
L
K
V
F
D
Y
P
E
H
G
G
V
A
M
M
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.5
79.8
N.A.
95.1
94.6
N.A.
82.5
88.7
86.5
84
N.A.
N.A.
N.A.
65.7
69.9
Protein Similarity:
100
99.7
99.5
83.9
N.A.
97.1
96.9
N.A.
86.7
93.5
92.2
92
N.A.
N.A.
N.A.
76.3
81.6
P-Site Identity:
100
100
100
73.3
N.A.
80
80
N.A.
93.3
100
66.6
73.3
N.A.
N.A.
N.A.
26.6
40
P-Site Similarity:
100
100
100
93.3
N.A.
86.6
86.6
N.A.
100
100
80
73.3
N.A.
N.A.
N.A.
46.6
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
58.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
71.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
24
0
0
16
8
24
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
0
0
0
0
0
77
0
0
0
8
% D
% Glu:
0
0
0
8
0
0
0
8
0
0
0
0
0
8
0
% E
% Phe:
0
0
85
8
0
0
85
0
0
0
0
0
0
0
0
% F
% Gly:
85
0
0
0
0
0
0
0
0
8
8
93
0
54
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
24
0
77
0
0
0
0
8
62
0
0
0
16
0
% K
% Leu:
8
0
8
0
31
8
0
0
0
0
0
0
0
0
0
% L
% Met:
0
8
0
0
54
0
0
0
0
0
0
0
0
8
8
% M
% Asn:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
8
% N
% Pro:
0
0
0
0
0
0
8
0
85
8
0
0
0
0
8
% P
% Gln:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
8
8
0
0
0
0
0
16
0
0
8
0
77
8
0
% S
% Thr:
0
62
0
0
0
0
0
70
0
0
0
0
8
0
8
% T
% Val:
0
0
8
0
0
77
8
0
0
0
0
8
0
0
39
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _