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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IDH2
All Species:
49.39
Human Site:
Y247
Identified Species:
90.56
UniProt:
P48735
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48735
NP_002159.2
452
50909
Y247
I
Q
K
K
W
P
L
Y
M
S
T
K
N
T
I
Chimpanzee
Pan troglodytes
XP_510589
452
50861
Y247
I
Q
K
K
W
P
L
Y
M
S
T
K
N
T
I
Rhesus Macaque
Macaca mulatta
XP_001095686
452
50865
Y247
I
Q
K
K
W
P
L
Y
M
S
T
K
N
T
I
Dog
Lupus familis
XP_536192
517
57031
Y313
I
Q
K
K
W
P
L
Y
M
S
T
K
N
T
I
Cat
Felis silvestris
Mouse
Mus musculus
P54071
452
50888
Y247
I
Q
K
K
W
P
L
Y
L
S
T
K
N
T
I
Rat
Rattus norvegicus
P56574
452
50949
Y247
I
Q
K
K
W
P
L
Y
L
S
T
K
N
T
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507484
450
50551
Y246
I
Q
K
K
W
P
L
Y
M
S
T
K
N
T
I
Chicken
Gallus gallus
NP_001026770
452
50451
Y247
I
Q
K
K
W
P
L
Y
M
S
T
K
N
T
I
Frog
Xenopus laevis
NP_001080321
454
50741
Y248
I
Q
K
K
W
P
L
Y
M
S
T
K
N
T
I
Zebra Danio
Brachydanio rerio
NP_955858
449
50378
Y245
I
Q
K
K
W
P
L
Y
M
S
T
K
N
T
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_509875
435
49027
Y230
L
M
K
Q
W
P
L
Y
L
S
T
K
N
T
I
Sea Urchin
Strong. purpuratus
XP_001176537
449
50176
Y247
L
A
K
K
W
P
L
Y
L
S
T
K
N
T
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P41939
412
46544
K224
K
K
Y
D
G
K
F
K
D
V
F
E
A
M
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.5
79.8
N.A.
95.1
94.6
N.A.
82.5
88.7
86.5
84
N.A.
N.A.
N.A.
65.7
69.9
Protein Similarity:
100
99.7
99.5
83.9
N.A.
97.1
96.9
N.A.
86.7
93.5
92.2
92
N.A.
N.A.
N.A.
76.3
81.6
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
100
100
100
100
N.A.
N.A.
N.A.
73.3
80
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
N.A.
N.A.
93.3
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
58.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
71.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
0
0
8
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% E
% Phe:
0
0
0
0
0
0
8
0
0
0
8
0
0
0
0
% F
% Gly:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
77
0
0
0
0
0
0
0
0
0
0
0
0
0
93
% I
% Lys:
8
8
93
85
0
8
0
8
0
0
0
93
0
0
0
% K
% Leu:
16
0
0
0
0
0
93
0
31
0
0
0
0
0
0
% L
% Met:
0
8
0
0
0
0
0
0
62
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
93
0
0
% N
% Pro:
0
0
0
0
0
93
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
77
0
8
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
93
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
93
0
0
93
0
% T
% Val:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% V
% Trp:
0
0
0
0
93
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
93
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _