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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IDH2
All Species:
48.48
Human Site:
Y285
Identified Species:
88.89
UniProt:
P48735
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48735
NP_002159.2
452
50909
Y285
F
D
K
N
K
I
W
Y
E
H
R
L
I
D
D
Chimpanzee
Pan troglodytes
XP_510589
452
50861
Y285
F
D
K
N
K
I
W
Y
E
H
R
L
I
D
D
Rhesus Macaque
Macaca mulatta
XP_001095686
452
50865
Y285
F
D
K
N
K
I
W
Y
E
H
R
L
I
D
D
Dog
Lupus familis
XP_536192
517
57031
Y351
F
D
K
N
K
I
W
Y
E
H
R
L
I
D
D
Cat
Felis silvestris
Mouse
Mus musculus
P54071
452
50888
Y285
F
D
K
N
K
I
W
Y
E
H
R
L
I
D
D
Rat
Rattus norvegicus
P56574
452
50949
Y285
F
D
K
N
K
I
W
Y
E
H
R
L
I
D
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507484
450
50551
Y284
F
D
K
N
K
I
W
Y
E
H
R
L
I
D
D
Chicken
Gallus gallus
NP_001026770
452
50451
Y285
F
D
K
L
K
I
W
Y
E
H
R
L
I
D
D
Frog
Xenopus laevis
NP_001080321
454
50741
Y286
F
D
K
V
K
I
W
Y
E
H
R
L
I
D
D
Zebra Danio
Brachydanio rerio
NP_955858
449
50378
Y283
F
D
K
L
K
I
W
Y
E
H
R
L
I
D
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_509875
435
49027
Y268
F
K
N
N
K
I
W
Y
E
H
R
L
I
D
D
Sea Urchin
Strong. purpuratus
XP_001176537
449
50176
Y285
Y
D
S
A
G
I
W
Y
E
H
R
L
I
D
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P41939
412
46544
S261
M
V
A
Q
M
L
K
S
K
G
G
Y
I
I
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.5
79.8
N.A.
95.1
94.6
N.A.
82.5
88.7
86.5
84
N.A.
N.A.
N.A.
65.7
69.9
Protein Similarity:
100
99.7
99.5
83.9
N.A.
97.1
96.9
N.A.
86.7
93.5
92.2
92
N.A.
N.A.
N.A.
76.3
81.6
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
93.3
93.3
93.3
N.A.
N.A.
N.A.
86.6
73.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
93.3
93.3
93.3
N.A.
N.A.
N.A.
86.6
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
58.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
71.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
85
0
0
0
0
0
0
0
0
0
0
0
93
93
% D
% Glu:
0
0
0
0
0
0
0
0
93
0
0
0
0
0
0
% E
% Phe:
85
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
8
0
0
0
0
8
8
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
93
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
93
0
0
0
0
0
0
100
8
0
% I
% Lys:
0
8
77
0
85
0
8
0
8
0
0
0
0
0
0
% K
% Leu:
0
0
0
16
0
8
0
0
0
0
0
93
0
0
0
% L
% Met:
8
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
62
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
93
0
0
0
0
% R
% Ser:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
8
0
8
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
93
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
93
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _