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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CG
All Species:
21.82
Human Site:
S446
Identified Species:
40
UniProt:
P48736
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48736
NP_002640.2
1102
126454
S446
P
A
L
S
S
K
A
S
A
E
S
P
S
S
E
Chimpanzee
Pan troglodytes
XP_001162884
1102
126413
S446
P
A
L
S
S
K
A
S
A
E
S
P
S
S
E
Rhesus Macaque
Macaca mulatta
XP_001091036
1102
126515
S446
P
A
V
S
S
K
A
S
A
E
S
P
S
S
E
Dog
Lupus familis
XP_540385
1104
126411
S446
P
T
L
S
A
K
A
S
A
D
A
P
G
A
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHG7
1102
126343
S446
P
S
L
S
S
K
A
S
A
E
T
P
G
S
E
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
K424
T
K
T
I
N
P
S
K
Y
Q
T
I
R
K
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
I427
C
P
L
A
W
G
N
I
N
L
F
D
Y
T
D
Chicken
Gallus gallus
XP_415951
1106
127994
S449
S
T
K
T
N
L
Q
S
H
E
S
P
N
S
D
Frog
Xenopus laevis
Q6AZN6
886
101139
L277
H
H
K
L
A
R
S
L
R
S
G
P
S
D
H
Zebra Danio
Brachydanio rerio
NP_998471
1098
126892
T441
V
S
C
G
K
A
Q
T
Q
T
S
K
E
T
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
S494
Y
M
K
D
M
P
P
S
A
V
L
S
I
R
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
H204
K
E
Q
E
S
T
K
H
G
S
S
H
L
F
V
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
F266
K
Y
H
S
T
L
K
F
Y
D
P
D
Q
P
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
98.8
92.1
N.A.
94
31.3
N.A.
31.3
84.6
20.5
71.8
N.A.
N.A.
N.A.
25.7
N.A.
Protein Similarity:
100
99.9
99.5
95.3
N.A.
96.7
51.6
N.A.
51
91
39.8
84.3
N.A.
N.A.
N.A.
47.2
N.A.
P-Site Identity:
100
100
93.3
53.3
N.A.
80
0
N.A.
6.6
33.3
13.3
13.3
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
100
100
100
80
N.A.
93.3
26.6
N.A.
26.6
60
33.3
33.3
N.A.
N.A.
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.7
22.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.8
41.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
24
0
8
16
8
39
0
47
0
8
0
0
8
8
% A
% Cys:
8
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
0
0
0
16
0
16
0
8
16
% D
% Glu:
0
8
0
8
0
0
0
0
0
39
0
0
8
0
39
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
8
0
0
8
0
% F
% Gly:
0
0
0
8
0
8
0
0
8
0
8
0
16
0
8
% G
% His:
8
8
8
0
0
0
0
8
8
0
0
8
0
0
8
% H
% Ile:
0
0
0
8
0
0
0
8
0
0
0
8
8
0
0
% I
% Lys:
16
8
24
0
8
39
16
8
0
0
0
8
0
8
0
% K
% Leu:
0
0
39
8
0
16
0
8
0
8
8
0
8
0
0
% L
% Met:
0
8
0
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
16
0
8
0
8
0
0
0
8
0
8
% N
% Pro:
39
8
0
0
0
16
8
0
0
0
8
54
0
8
0
% P
% Gln:
0
0
8
0
0
0
16
0
8
8
0
0
8
0
0
% Q
% Arg:
0
0
0
0
0
8
0
0
8
0
0
0
8
8
0
% R
% Ser:
8
16
0
47
39
0
16
54
0
16
47
8
31
39
0
% S
% Thr:
8
16
8
8
8
8
0
8
0
8
16
0
0
16
0
% T
% Val:
8
0
8
0
0
0
0
0
0
8
0
0
0
0
16
% V
% Trp:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
8
0
0
0
0
0
0
16
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _