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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CG
All Species:
17.27
Human Site:
S777
Identified Species:
31.67
UniProt:
P48736
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48736
NP_002640.2
1102
126454
S777
K
L
E
N
L
Q
N
S
Q
L
P
E
S
F
R
Chimpanzee
Pan troglodytes
XP_001162884
1102
126413
S777
K
L
E
N
L
Q
N
S
Q
L
P
E
S
F
R
Rhesus Macaque
Macaca mulatta
XP_001091036
1102
126515
S777
K
L
E
N
L
Q
N
S
Q
L
P
K
S
F
R
Dog
Lupus familis
XP_540385
1104
126411
L779
K
L
E
N
L
Q
N
L
N
L
P
E
S
F
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHG7
1102
126343
S777
K
L
E
S
L
Q
N
S
N
L
P
E
S
F
R
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
L755
Q
S
A
Y
R
E
A
L
S
D
L
Q
S
P
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
L748
R
P
D
F
M
D
A
L
Q
G
F
I
S
P
L
Chicken
Gallus gallus
XP_415951
1106
127994
S780
K
L
E
K
L
Q
G
S
K
L
P
E
S
F
R
Frog
Xenopus laevis
Q6AZN6
886
101139
L584
G
D
N
E
K
M
N
L
S
E
F
E
P
I
P
Zebra Danio
Brachydanio rerio
NP_998471
1098
126892
L772
K
L
E
G
L
Q
V
L
G
L
P
D
S
F
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
M836
L
R
S
I
S
H
K
M
E
N
M
D
S
P
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
L511
L
G
G
L
L
S
E
L
T
Y
F
E
E
P
I
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
L573
L
E
T
K
V
R
P
L
V
K
V
R
P
I
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
98.8
92.1
N.A.
94
31.3
N.A.
31.3
84.6
20.5
71.8
N.A.
N.A.
N.A.
25.7
N.A.
Protein Similarity:
100
99.9
99.5
95.3
N.A.
96.7
51.6
N.A.
51
91
39.8
84.3
N.A.
N.A.
N.A.
47.2
N.A.
P-Site Identity:
100
100
93.3
86.6
N.A.
86.6
6.6
N.A.
13.3
80
13.3
60
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
86.6
N.A.
93.3
26.6
N.A.
33.3
86.6
13.3
73.3
N.A.
N.A.
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.7
22.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.8
41.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
16
0
0
0
0
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
8
0
0
8
0
0
0
8
0
16
0
0
0
% D
% Glu:
0
8
54
8
0
8
8
0
8
8
0
54
8
0
0
% E
% Phe:
0
0
0
8
0
0
0
0
0
0
24
0
0
54
0
% F
% Gly:
8
8
8
8
0
0
8
0
8
8
0
0
0
0
0
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
0
0
0
0
0
0
8
0
16
8
% I
% Lys:
54
0
0
16
8
0
8
0
8
8
0
8
0
0
8
% K
% Leu:
24
54
0
8
62
0
0
54
0
54
8
0
0
0
24
% L
% Met:
0
0
0
0
8
8
0
8
0
0
8
0
0
0
0
% M
% Asn:
0
0
8
31
0
0
47
0
16
8
0
0
0
0
0
% N
% Pro:
0
8
0
0
0
0
8
0
0
0
54
0
16
31
8
% P
% Gln:
8
0
0
0
0
54
0
0
31
0
0
8
0
0
0
% Q
% Arg:
8
8
0
0
8
8
0
0
0
0
0
8
0
0
47
% R
% Ser:
0
8
8
8
8
8
0
39
16
0
0
0
77
0
0
% S
% Thr:
0
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% T
% Val:
0
0
0
0
8
0
8
0
8
0
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _