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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CG
All Species:
25.45
Human Site:
Y196
Identified Species:
46.67
UniProt:
P48736
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48736
NP_002640.2
1102
126454
Y196
A
S
R
D
P
K
L
Y
A
M
H
P
W
V
T
Chimpanzee
Pan troglodytes
XP_001162884
1102
126413
Y196
A
S
R
D
P
K
L
Y
A
M
H
P
W
V
T
Rhesus Macaque
Macaca mulatta
XP_001091036
1102
126515
Y196
A
S
R
D
P
R
L
Y
A
M
H
P
W
V
T
Dog
Lupus familis
XP_540385
1104
126411
Y196
A
G
R
D
P
E
L
Y
A
M
H
P
W
V
T
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHG7
1102
126343
Y196
A
G
R
D
A
K
L
Y
A
M
H
P
W
V
T
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
G195
L
E
D
K
L
Y
G
G
K
L
V
V
A
V
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
I191
K
L
D
K
G
Q
I
I
V
V
I
W
V
I
V
Chicken
Gallus gallus
XP_415951
1106
127994
Y196
A
C
R
D
P
K
L
Y
A
M
H
P
W
T
T
Frog
Xenopus laevis
Q6AZN6
886
101139
V59
E
T
C
S
D
L
Y
V
T
C
Q
V
F
A
E
Zebra Danio
Brachydanio rerio
NP_998471
1098
126892
Y197
S
D
R
D
P
N
L
Y
S
M
D
P
W
M
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
R206
E
S
L
D
E
E
L
R
Q
F
R
A
S
L
W
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
S48
P
E
L
M
L
I
G
S
N
V
F
P
S
S
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
98.8
92.1
N.A.
94
31.3
N.A.
31.3
84.6
20.5
71.8
N.A.
N.A.
N.A.
25.7
N.A.
Protein Similarity:
100
99.9
99.5
95.3
N.A.
96.7
51.6
N.A.
51
91
39.8
84.3
N.A.
N.A.
N.A.
47.2
N.A.
P-Site Identity:
100
100
93.3
86.6
N.A.
86.6
6.6
N.A.
0
86.6
0
60
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
86.6
13.3
N.A.
26.6
86.6
13.3
80
N.A.
N.A.
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.7
22.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.8
41.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
47
0
0
0
8
0
0
0
47
0
0
8
8
8
0
% A
% Cys:
0
8
8
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
8
16
62
8
0
0
0
0
0
8
0
0
0
8
% D
% Glu:
16
16
0
0
8
16
0
0
0
0
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
8
0
8
0
0
% F
% Gly:
0
16
0
0
8
0
16
8
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
47
0
0
0
8
% H
% Ile:
0
0
0
0
0
8
8
8
0
0
8
0
0
8
0
% I
% Lys:
8
0
0
16
0
31
0
0
8
0
0
0
0
0
0
% K
% Leu:
8
8
16
0
16
8
62
0
0
8
0
0
0
8
0
% L
% Met:
0
0
0
8
0
0
0
0
0
54
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
8
0
0
8
0
0
0
0
0
0
% N
% Pro:
8
0
0
0
47
0
0
0
0
0
0
62
0
0
0
% P
% Gln:
0
0
0
0
0
8
0
0
8
0
8
0
0
0
0
% Q
% Arg:
0
0
54
0
0
8
0
8
0
0
8
0
0
0
0
% R
% Ser:
8
31
0
8
0
0
0
8
8
0
0
0
16
8
0
% S
% Thr:
0
8
0
0
0
0
0
0
8
0
0
0
0
8
54
% T
% Val:
0
0
0
0
0
0
0
8
8
16
8
16
8
47
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
8
54
0
8
% W
% Tyr:
0
0
0
0
0
8
8
54
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _