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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CG
All Species:
25.76
Human Site:
Y589
Identified Species:
47.22
UniProt:
P48736
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48736
NP_002640.2
1102
126454
Y589
S
L
K
H
P
K
A
Y
P
K
L
F
S
S
V
Chimpanzee
Pan troglodytes
XP_001162884
1102
126413
Y589
S
L
K
H
P
K
A
Y
P
K
L
F
S
S
V
Rhesus Macaque
Macaca mulatta
XP_001091036
1102
126515
Y589
S
L
K
H
P
K
A
Y
P
K
L
F
S
S
V
Dog
Lupus familis
XP_540385
1104
126411
Y591
S
L
K
H
P
K
A
Y
P
K
L
F
S
S
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHG7
1102
126343
Y589
S
L
K
H
P
K
A
Y
P
K
L
F
S
S
V
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
N568
L
R
Q
D
C
R
E
N
F
P
Q
S
L
P
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
L565
C
V
T
T
P
E
I
L
P
K
L
L
L
S
V
Chicken
Gallus gallus
XP_415951
1106
127994
Y592
S
I
K
H
P
K
A
Y
P
K
L
L
S
S
V
Frog
Xenopus laevis
Q6AZN6
886
101139
N407
V
Q
A
L
K
Y
E
N
F
E
D
I
K
S
G
Zebra Danio
Brachydanio rerio
NP_998471
1098
126892
Y584
C
M
R
D
P
K
A
Y
P
K
F
L
S
S
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
P648
R
Y
I
Q
K
Q
E
P
D
L
L
I
V
L
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
Q334
C
V
E
W
S
D
V
Q
E
A
K
Q
A
I
Q
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
K396
S
Y
A
V
N
R
L
K
K
A
S
D
K
E
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
98.8
92.1
N.A.
94
31.3
N.A.
31.3
84.6
20.5
71.8
N.A.
N.A.
N.A.
25.7
N.A.
Protein Similarity:
100
99.9
99.5
95.3
N.A.
96.7
51.6
N.A.
51
91
39.8
84.3
N.A.
N.A.
N.A.
47.2
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
40
86.6
6.6
60
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
13.3
N.A.
53.3
93.3
13.3
73.3
N.A.
N.A.
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.7
22.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.8
41.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
16
0
0
0
54
0
0
16
0
0
8
0
0
% A
% Cys:
24
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
16
0
8
0
0
8
0
8
8
0
0
0
% D
% Glu:
0
0
8
0
0
8
24
0
8
8
0
0
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
16
0
8
39
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% G
% His:
0
0
0
47
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
8
0
0
0
8
0
0
0
0
16
0
8
0
% I
% Lys:
0
0
47
0
16
54
0
8
8
62
8
0
16
0
8
% K
% Leu:
8
39
0
8
0
0
8
8
0
8
62
24
16
8
8
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
16
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
62
0
0
8
62
8
0
0
0
8
0
% P
% Gln:
0
8
8
8
0
8
0
8
0
0
8
8
0
0
8
% Q
% Arg:
8
8
8
0
0
16
0
0
0
0
0
0
0
0
0
% R
% Ser:
54
0
0
0
8
0
0
0
0
0
8
8
54
70
8
% S
% Thr:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
8
16
0
8
0
0
8
0
0
0
0
0
8
0
62
% V
% Trp:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
16
0
0
0
8
0
54
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _