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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CG
All Species:
27.27
Human Site:
Y787
Identified Species:
50
UniProt:
P48736
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48736
NP_002640.2
1102
126454
Y787
P
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
Chimpanzee
Pan troglodytes
XP_001162884
1102
126413
Y787
P
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
Rhesus Macaque
Macaca mulatta
XP_001091036
1102
126515
Y787
P
K
S
F
R
V
P
Y
D
P
G
L
K
A
G
Dog
Lupus familis
XP_540385
1104
126411
Y789
P
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHG7
1102
126343
Y787
P
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
C765
L
Q
S
P
L
N
P
C
V
I
L
S
E
L
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505664
1068
124323
A758
F
I
S
P
L
N
P
A
H
Q
L
G
N
L
R
Chicken
Gallus gallus
XP_415951
1106
127994
Y790
P
E
S
F
R
V
P
Y
D
P
G
L
R
A
G
Frog
Xenopus laevis
Q6AZN6
886
101139
L594
F
E
P
I
P
L
P
L
E
P
Q
V
K
I
R
Zebra Danio
Brachydanio rerio
NP_998471
1098
126892
Y782
P
D
S
F
K
V
P
Y
D
P
G
L
R
A
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
V846
M
D
S
P
L
D
P
V
Y
K
L
G
E
M
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
P521
F
E
E
P
I
R
S
P
L
T
P
N
V
L
I
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
L583
V
R
P
I
A
L
P
L
D
P
D
V
L
I
C
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
98.8
92.1
N.A.
94
31.3
N.A.
31.3
84.6
20.5
71.8
N.A.
N.A.
N.A.
25.7
N.A.
Protein Similarity:
100
99.9
99.5
95.3
N.A.
96.7
51.6
N.A.
51
91
39.8
84.3
N.A.
N.A.
N.A.
47.2
N.A.
P-Site Identity:
100
100
93.3
100
N.A.
100
13.3
N.A.
13.3
93.3
26.6
80
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
26.6
N.A.
13.3
100
46.6
100
N.A.
N.A.
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.7
22.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.8
41.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
8
0
0
0
0
0
54
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
8
% C
% Asp:
0
16
0
0
0
8
0
0
62
0
8
0
0
0
0
% D
% Glu:
0
54
8
0
0
0
0
0
8
0
0
0
16
0
0
% E
% Phe:
24
0
0
54
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
54
16
0
0
54
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
8
0
16
8
0
0
0
0
8
0
0
0
16
16
% I
% Lys:
0
8
0
0
8
0
0
0
0
8
0
0
47
0
0
% K
% Leu:
8
0
0
0
24
16
0
16
8
0
24
54
8
24
0
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
16
0
0
0
0
0
8
8
0
0
% N
% Pro:
54
0
16
31
8
0
93
8
0
70
8
0
0
0
0
% P
% Gln:
0
8
0
0
0
0
0
0
0
8
8
0
0
0
0
% Q
% Arg:
0
8
0
0
47
8
0
0
0
0
0
0
16
0
16
% R
% Ser:
0
0
77
0
0
0
8
0
0
0
0
8
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% T
% Val:
8
0
0
0
0
54
0
8
8
0
0
16
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
54
8
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _