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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TDO2
All Species:
36.06
Human Site:
S278
Identified Species:
66.11
UniProt:
P48775
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48775
NP_005642.1
406
47872
S278
K
R
H
E
H
L
L
S
K
G
E
R
R
L
S
Chimpanzee
Pan troglodytes
XP_001140187
406
47819
S278
K
R
H
E
H
L
L
S
K
G
E
R
R
L
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532700
406
47838
S278
K
R
H
E
H
L
Y
S
K
G
E
R
R
L
S
Cat
Felis silvestris
Mouse
Mus musculus
P48776
406
47738
S278
K
R
H
D
Y
L
L
S
K
G
E
R
R
L
S
Rat
Rattus norvegicus
P21643
406
47838
S278
K
R
H
D
Y
L
L
S
K
G
E
R
R
L
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510047
406
48019
S278
K
R
H
E
H
L
L
S
K
G
E
R
R
L
S
Chicken
Gallus gallus
XP_420377
406
47669
S278
K
R
H
E
H
L
L
S
K
G
E
R
R
L
S
Frog
Xenopus laevis
Q5U4U6
406
47659
S278
R
R
H
E
H
L
L
S
K
G
E
R
R
L
S
Zebra Danio
Brachydanio rerio
Q7SY53
407
47403
S277
K
R
H
E
H
L
L
S
K
G
E
R
R
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P20351
379
44402
F252
R
E
V
Y
R
S
I
F
D
P
A
V
H
D
A
Honey Bee
Apis mellifera
XP_394304
392
45793
N264
I
F
N
E
S
L
H
N
A
L
V
S
R
G
E
Nematode Worm
Caenorhab. elegans
Q09474
403
46698
H275
D
P
R
Q
H
E
Q
H
I
R
N
G
N
R
L
Sea Urchin
Strong. purpuratus
XP_798322
455
51404
A265
D
K
Y
K
A
L
L
A
R
G
D
V
R
I
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
N.A.
94.3
N.A.
88.6
88.6
N.A.
88.4
83.7
81
74.9
N.A.
54.1
50.9
52.2
46.1
Protein Similarity:
100
99.7
N.A.
97.7
N.A.
95.5
95.8
N.A.
94.5
92.3
90.6
85.2
N.A.
70.1
70.1
70.6
61.7
P-Site Identity:
100
100
N.A.
93.3
N.A.
86.6
86.6
N.A.
100
100
93.3
100
N.A.
0
20
6.6
33.3
P-Site Similarity:
100
100
N.A.
93.3
N.A.
100
100
N.A.
100
100
100
100
N.A.
20
33.3
13.3
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
8
8
0
8
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
16
0
0
16
0
0
0
0
8
0
8
0
0
8
0
% D
% Glu:
0
8
0
62
0
8
0
0
0
0
70
0
0
0
8
% E
% Phe:
0
8
0
0
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
77
0
8
0
8
0
% G
% His:
0
0
70
0
62
0
8
8
0
0
0
0
8
0
0
% H
% Ile:
8
0
0
0
0
0
8
0
8
0
0
0
0
8
0
% I
% Lys:
62
8
0
8
0
0
0
0
70
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
85
70
0
0
8
0
0
0
70
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
8
0
0
8
0
8
0
0
% N
% Pro:
0
8
0
0
0
0
0
0
0
8
0
0
0
0
0
% P
% Gln:
0
0
0
8
0
0
8
0
0
0
0
0
0
0
0
% Q
% Arg:
16
70
8
0
8
0
0
0
8
8
0
70
85
8
0
% R
% Ser:
0
0
0
0
8
8
0
70
0
0
0
8
0
0
77
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
8
0
0
0
0
0
0
0
8
16
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
8
16
0
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _