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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TDO2
All Species:
18.79
Human Site:
S28
Identified Species:
34.44
UniProt:
P48775
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48775
NP_005642.1
406
47872
S28
E
G
S
E
E
D
K
S
Q
T
G
V
N
R
A
Chimpanzee
Pan troglodytes
XP_001140187
406
47819
S28
E
G
S
E
E
D
K
S
Q
T
G
V
N
R
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532700
406
47838
S28
E
D
N
E
E
D
K
S
Q
T
G
V
N
R
A
Cat
Felis silvestris
Mouse
Mus musculus
P48776
406
47738
A28
E
D
N
E
E
D
R
A
Q
T
G
V
N
R
A
Rat
Rattus norvegicus
P21643
406
47838
A28
E
D
N
E
E
D
G
A
Q
T
G
V
N
R
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510047
406
48019
S28
E
D
C
E
E
D
K
S
Q
K
G
V
N
K
A
Chicken
Gallus gallus
XP_420377
406
47669
S28
K
D
E
K
G
D
K
S
Q
E
G
I
N
K
A
Frog
Xenopus laevis
Q5U4U6
406
47659
S28
E
D
K
H
E
D
N
S
Q
E
G
L
N
K
A
Zebra Danio
Brachydanio rerio
Q7SY53
407
47403
N32
D
G
S
Q
G
G
V
N
K
A
A
K
G
G
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P20351
379
44402
E22
S
A
V
P
L
T
T
E
V
G
K
I
Y
G
E
Honey Bee
Apis mellifera
XP_394304
392
45793
E28
A
E
G
M
L
Y
G
E
Y
L
R
L
D
K
I
Nematode Worm
Caenorhab. elegans
Q09474
403
46698
V28
G
E
E
C
Q
Q
G
V
N
K
V
E
M
G
F
Sea Urchin
Strong. purpuratus
XP_798322
455
51404
G28
D
D
K
K
L
T
Y
G
S
Y
L
Q
L
D
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
N.A.
94.3
N.A.
88.6
88.6
N.A.
88.4
83.7
81
74.9
N.A.
54.1
50.9
52.2
46.1
Protein Similarity:
100
99.7
N.A.
97.7
N.A.
95.5
95.8
N.A.
94.5
92.3
90.6
85.2
N.A.
70.1
70.1
70.6
61.7
P-Site Identity:
100
100
N.A.
86.6
N.A.
73.3
73.3
N.A.
73.3
46.6
53.3
13.3
N.A.
0
0
0
0
P-Site Similarity:
100
100
N.A.
93.3
N.A.
93.3
86.6
N.A.
80
73.3
66.6
40
N.A.
6.6
20
6.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
0
0
0
0
16
0
8
8
0
0
0
62
% A
% Cys:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
16
54
0
0
0
62
0
0
0
0
0
0
8
8
0
% D
% Glu:
54
16
16
47
54
0
0
16
0
16
0
8
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
8
24
8
0
16
8
24
8
0
8
62
0
8
24
0
% G
% His:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
16
0
0
16
% I
% Lys:
8
0
16
16
0
0
39
0
8
16
8
8
0
31
8
% K
% Leu:
0
0
0
0
24
0
0
0
0
8
8
16
8
0
0
% L
% Met:
0
0
0
8
0
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
0
24
0
0
0
8
8
8
0
0
0
62
0
0
% N
% Pro:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
8
8
8
0
0
62
0
0
8
0
0
0
% Q
% Arg:
0
0
0
0
0
0
8
0
0
0
8
0
0
39
0
% R
% Ser:
8
0
24
0
0
0
0
47
8
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
16
8
0
0
39
0
0
0
0
0
% T
% Val:
0
0
8
0
0
0
8
8
8
0
8
47
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
8
0
8
8
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _