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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TDO2
All Species:
26.36
Human Site:
Y394
Identified Species:
48.33
UniProt:
P48775
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P48775
NP_005642.1
406
47872
Y394
K
F
L
Y
T
A
E
Y
C
D
S
S
Y
F
S
Chimpanzee
Pan troglodytes
XP_001140187
406
47819
Y394
K
F
L
Y
T
A
E
Y
C
D
S
S
Y
F
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532700
406
47838
Y394
K
F
L
Y
T
A
E
Y
C
D
S
S
Y
F
S
Cat
Felis silvestris
Mouse
Mus musculus
P48776
406
47738
Y394
K
F
L
Y
T
A
E
Y
S
D
S
S
Y
F
S
Rat
Rattus norvegicus
P21643
406
47838
Y394
K
F
L
Y
T
A
E
Y
S
D
S
S
Y
F
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510047
406
48019
Y394
K
F
L
Y
M
A
E
Y
C
D
S
S
Y
F
S
Chicken
Gallus gallus
XP_420377
406
47669
Y394
K
F
L
Y
T
A
E
Y
C
D
S
S
Y
F
S
Frog
Xenopus laevis
Q5U4U6
406
47659
C394
K
F
L
Y
T
A
E
C
C
D
S
S
Y
F
S
Zebra Danio
Brachydanio rerio
Q7SY53
407
47403
C393
K
F
P
Y
T
A
E
C
Y
D
S
S
Y
N
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P20351
379
44402
E368
E
A
I
P
P
L
D
E
T
I
R
K
K
L
I
Honey Bee
Apis mellifera
XP_394304
392
45793
L380
T
K
E
M
K
S
M
L
S
V
S
C
N
G
W
Nematode Worm
Caenorhab. elegans
Q09474
403
46698
H391
M
V
K
T
L
S
E
H
S
N
L
S
H
S
Q
Sea Urchin
Strong. purpuratus
XP_798322
455
51404
L381
R
T
L
S
I
P
N
L
N
T
S
V
D
G
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
N.A.
94.3
N.A.
88.6
88.6
N.A.
88.4
83.7
81
74.9
N.A.
54.1
50.9
52.2
46.1
Protein Similarity:
100
99.7
N.A.
97.7
N.A.
95.5
95.8
N.A.
94.5
92.3
90.6
85.2
N.A.
70.1
70.1
70.6
61.7
P-Site Identity:
100
100
N.A.
100
N.A.
93.3
93.3
N.A.
93.3
100
93.3
73.3
N.A.
0
6.6
13.3
20
P-Site Similarity:
100
100
N.A.
100
N.A.
93.3
93.3
N.A.
93.3
100
93.3
73.3
N.A.
20
13.3
40
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
70
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
16
47
0
0
8
0
0
0
% C
% Asp:
0
0
0
0
0
0
8
0
0
70
0
0
8
0
0
% D
% Glu:
8
0
8
0
0
0
77
8
0
0
0
0
0
0
0
% E
% Phe:
0
70
0
0
0
0
0
0
0
0
0
0
0
62
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
16
0
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% H
% Ile:
0
0
8
0
8
0
0
0
0
8
0
0
0
0
8
% I
% Lys:
70
8
8
0
8
0
0
0
0
0
0
8
8
0
0
% K
% Leu:
0
0
70
0
8
8
0
16
0
0
8
0
0
8
0
% L
% Met:
8
0
0
8
8
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
8
8
0
0
8
8
0
% N
% Pro:
0
0
8
8
8
8
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Q
% Arg:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% R
% Ser:
0
0
0
8
0
16
0
0
31
0
85
77
0
8
77
% S
% Thr:
8
8
0
8
62
0
0
0
8
8
0
0
0
0
0
% T
% Val:
0
8
0
0
0
0
0
0
0
8
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
0
0
70
0
0
0
54
8
0
0
0
70
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _