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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NR2C2
All Species:
27.88
Human Site:
S219
Identified Species:
51.11
UniProt:
P49116
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49116
NP_003289.2
596
65414
S219
Y
I
R
K
D
L
R
S
P
L
I
A
T
P
T
Chimpanzee
Pan troglodytes
XP_001158452
596
65396
S219
Y
I
R
K
D
L
R
S
P
L
I
A
T
P
T
Rhesus Macaque
Macaca mulatta
XP_001091445
632
69119
R253
I
N
K
H
H
R
N
R
C
Q
F
C
R
L
K
Dog
Lupus familis
XP_541755
633
69174
S256
Y
I
R
K
D
L
R
S
P
L
I
A
T
P
T
Cat
Felis silvestris
Mouse
Mus musculus
P49117
596
65221
S219
Y
I
R
K
D
L
R
S
P
L
I
A
T
P
T
Rat
Rattus norvegicus
P55094
596
65326
S219
Y
I
R
K
D
L
R
S
P
L
I
A
T
P
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506287
596
65629
S219
Y
I
R
K
D
L
R
S
P
L
I
A
T
P
T
Chicken
Gallus gallus
O42101
501
57084
L138
M
Y
K
R
D
R
A
L
K
Q
Q
K
K
A
L
Frog
Xenopus laevis
Q6GN21
637
70767
S254
Y
I
R
K
D
L
R
S
P
L
A
A
T
T
T
Zebra Danio
Brachydanio rerio
Q06725
411
45463
S48
P
H
T
P
Q
T
P
S
Q
P
G
P
P
S
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P16375
543
57969
S180
T
P
S
S
Q
A
N
S
S
H
S
Q
S
S
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9N4B8
615
68010
P247
N
N
Q
Q
N
T
T
P
E
H
L
S
P
N
L
Sea Urchin
Strong. purpuratus
Q26622
583
63834
L203
T
F
V
T
G
S
V
L
A
G
G
D
M
K
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
100
86.2
93.2
N.A.
98.3
97.8
N.A.
94.1
24.3
57.9
29.8
N.A.
20.8
N.A.
21.1
51.3
Protein Similarity:
100
100
86.5
93.3
N.A.
98.8
98.8
N.A.
97.6
41.2
72.5
43.9
N.A.
37
N.A.
42.9
65.6
P-Site Identity:
100
100
0
100
N.A.
100
100
N.A.
100
6.6
86.6
13.3
N.A.
6.6
N.A.
0
0
P-Site Similarity:
100
100
6.6
100
N.A.
100
100
N.A.
100
20
86.6
13.3
N.A.
13.3
N.A.
33.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
8
0
8
0
8
54
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
8
0
0
0
% C
% Asp:
0
0
0
0
62
0
0
0
0
0
0
8
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
8
0
0
0
0
% F
% Gly:
0
0
0
0
8
0
0
0
0
8
16
0
0
0
0
% G
% His:
0
8
0
8
8
0
0
0
0
16
0
0
0
0
0
% H
% Ile:
8
54
0
0
0
0
0
0
0
0
47
0
0
0
0
% I
% Lys:
0
0
16
54
0
0
0
0
8
0
0
8
8
8
8
% K
% Leu:
0
0
0
0
0
54
0
16
0
54
8
0
0
8
16
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
8
16
0
0
8
0
16
0
0
0
0
0
0
8
8
% N
% Pro:
8
8
0
8
0
0
8
8
54
8
0
8
16
47
0
% P
% Gln:
0
0
8
8
16
0
0
0
8
16
8
8
0
0
0
% Q
% Arg:
0
0
54
8
0
16
54
8
0
0
0
0
8
0
0
% R
% Ser:
0
0
8
8
0
8
0
70
8
0
8
8
8
16
8
% S
% Thr:
16
0
8
8
0
16
8
0
0
0
0
0
54
8
62
% T
% Val:
0
0
8
0
0
0
8
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
54
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _