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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POU3F4 All Species: 12.12
Human Site: S123 Identified Species: 20.51
UniProt: P49335 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49335 NP_000298.2 361 39427 S123 A S P A P N P S I T S S G Q P
Chimpanzee Pan troglodytes Q7YR49 360 38582 V117 A S P E P C T V T P G A V K L
Rhesus Macaque Macaca mulatta Q5TM49 360 38511 V117 A S P E P C T V P T G A V K L
Dog Lupus familis XP_549108 361 39472 S123 A N P A P N P S I T S S G Q P
Cat Felis silvestris
Mouse Mus musculus P31360 445 47130 P181 A A A A H L P P S M G A S N G
Rat Rattus norvegicus P62516 361 39399 S123 A S P A P N S S I T S S G Q P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518292 306 33617 W88 L S V K K D S W A V E T L G E
Chicken Gallus gallus P15143 739 75964 Q165 M T Q I P L S Q P I Q I A Q H
Frog Xenopus laevis P70030 385 41967 S130 T G S T H L S S M A S S N G Q
Zebra Danio Brachydanio rerio P79746 378 41798 S130 T T A A H I P S M A T S N G Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P16241 427 45909 A140 S P H A A W H A P H A G H Y A
Honey Bee Apis mellifera XP_393686 460 49306 N179 V V P S A H Y N P S G G A A S
Nematode Worm Caenorhab. elegans P20268 380 42556 I125 I A S Q S S I I N Q T S V V T
Sea Urchin Strong. purpuratus XP_782909 467 49786 G141 S A A T W N T G N A H M A M P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 39.3 39.3 96.6 N.A. 53.9 98.6 N.A. 49 22.6 60.7 60.8 N.A. 45.9 45.6 41 43.9
Protein Similarity: 100 50.4 49.8 98.6 N.A. 60.9 98.8 N.A. 55.6 30.5 69.8 72.4 N.A. 53.6 53.7 52.3 53.5
P-Site Identity: 100 26.6 33.3 93.3 N.A. 20 93.3 N.A. 6.6 13.3 20 26.6 N.A. 6.6 6.6 6.6 13.3
P-Site Similarity: 100 40 46.6 100 N.A. 33.3 93.3 N.A. 20 20 26.6 46.6 N.A. 26.6 33.3 26.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 43 22 22 43 15 0 0 8 8 22 8 22 22 8 8 % A
% Cys: 0 0 0 0 0 15 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 15 0 0 0 0 0 0 8 0 0 0 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 8 0 0 0 0 0 8 0 0 29 15 22 22 8 % G
% His: 0 0 8 0 22 8 8 0 0 8 8 0 8 0 8 % H
% Ile: 8 0 0 8 0 8 8 8 22 8 0 8 0 0 0 % I
% Lys: 0 0 0 8 8 0 0 0 0 0 0 0 0 15 0 % K
% Leu: 8 0 0 0 0 22 0 0 0 0 0 0 8 0 15 % L
% Met: 8 0 0 0 0 0 0 0 15 8 0 8 0 8 0 % M
% Asn: 0 8 0 0 0 29 0 8 15 0 0 0 15 8 0 % N
% Pro: 0 8 43 0 43 0 29 8 29 8 0 0 0 0 29 % P
% Gln: 0 0 8 8 0 0 0 8 0 8 8 0 0 29 15 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 15 36 15 8 8 8 29 36 8 8 29 43 8 0 8 % S
% Thr: 15 15 0 15 0 0 22 0 8 29 15 8 0 0 8 % T
% Val: 8 8 8 0 0 0 0 15 0 8 0 0 22 8 0 % V
% Trp: 0 0 0 0 8 8 0 8 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 8 0 0 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _