KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK8
All Species:
23.03
Human Site:
S343
Identified Species:
46.06
UniProt:
P49336
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49336
NP_001251.1
464
53284
S343
L
E
D
P
L
P
T
S
D
V
F
A
G
C
Q
Chimpanzee
Pan troglodytes
XP_001156631
416
47693
C301
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_849851
463
53167
S343
L
E
D
P
L
P
T
S
D
V
F
A
G
C
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8R3L8
464
53191
S343
L
E
D
P
L
P
T
S
D
V
F
A
G
C
Q
Rat
Rattus norvegicus
Q03114
292
33236
Y179
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516816
464
53235
S343
L
E
D
P
L
P
T
S
D
V
F
A
G
C
Q
Chicken
Gallus gallus
XP_425638
464
53306
S343
L
E
D
P
L
P
T
S
D
V
F
A
G
C
Q
Frog
Xenopus laevis
Q66KH9
416
47745
C301
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
Zebra Danio
Brachydanio rerio
Q8JH47
464
53215
S343
L
E
E
P
L
P
T
S
D
V
F
A
G
C
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VT57
454
53663
A329
K
R
I
T
S
E
Q
A
M
Q
D
Q
Y
F
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P90866
588
67767
R356
R
K
M
E
R
P
P
R
E
T
D
D
V
F
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q84TI6
470
52779
R341
R
M
D
P
L
P
G
R
N
A
F
V
A
S
Q
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
89.6
N.A.
99.5
N.A.
98.9
26.5
N.A.
99.3
99.1
87
95.6
N.A.
71.1
N.A.
47.1
N.A.
Protein Similarity:
100
89.6
N.A.
99.5
N.A.
99.1
42.4
N.A.
99.3
99.5
88.7
97.4
N.A.
77.8
N.A.
60.2
N.A.
P-Site Identity:
100
6.6
N.A.
100
N.A.
100
0
N.A.
100
100
6.6
93.3
N.A.
6.6
N.A.
6.6
N.A.
P-Site Similarity:
100
20
N.A.
100
N.A.
100
6.6
N.A.
100
100
20
100
N.A.
13.3
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
9
17
0
9
0
9
0
50
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
17
0
0
0
0
0
50
0
% C
% Asp:
0
0
67
0
0
0
0
0
50
0
17
9
9
0
0
% D
% Glu:
0
50
9
9
0
9
0
0
9
0
0
0
0
0
0
% E
% Phe:
0
0
9
0
17
0
0
0
0
0
59
0
0
17
0
% F
% Gly:
0
0
0
9
0
0
25
0
0
0
0
0
50
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
9
0
0
0
0
0
0
17
0
9
0
0
0
% I
% Lys:
9
9
0
0
0
9
0
0
0
0
0
0
0
17
0
% K
% Leu:
50
9
0
0
59
0
9
0
0
0
0
0
0
0
0
% L
% Met:
0
9
9
0
0
0
0
0
9
0
0
0
0
9
0
% M
% Asn:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
9
% N
% Pro:
0
0
0
59
0
67
9
0
0
0
17
0
17
0
0
% P
% Gln:
0
0
0
0
0
0
9
0
17
9
0
9
0
0
67
% Q
% Arg:
17
9
0
0
9
0
0
17
0
0
0
0
0
0
17
% R
% Ser:
0
17
0
0
9
0
0
50
9
0
9
0
0
9
0
% S
% Thr:
17
0
0
9
0
0
50
0
0
17
0
0
0
0
0
% T
% Val:
9
0
0
17
0
0
0
0
0
50
0
9
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% W
% Tyr:
0
0
0
0
0
0
0
9
0
0
0
17
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _