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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDK8 All Species: 25.15
Human Site: Y296 Identified Species: 50.3
UniProt: P49336 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49336 NP_001251.1 464 53284 Y296 T N C S L I K Y M E K H K V K
Chimpanzee Pan troglodytes XP_001156631 416 47693 V254 K Y M E K H K V K P D S K A F
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_849851 463 53167 Y296 T N C S L I K Y M E K H K V K
Cat Felis silvestris
Mouse Mus musculus Q8R3L8 464 53191 Y296 T N C S L I K Y M E K H K V K
Rat Rattus norvegicus Q03114 292 33236 L132 R D L K P Q N L L I N R N G E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516816 464 53235 Y296 T N C S L I K Y M E K H K V K
Chicken Gallus gallus XP_425638 464 53306 Y296 T N C S L I K Y M E K H K V K
Frog Xenopus laevis Q66KH9 416 47745 V254 K Y M E K H K V K P D S K T F
Zebra Danio Brachydanio rerio Q8JH47 464 53215 Y296 T N C S L I K Y M E K H K V K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VT57 454 53663 D282 E H H T L T K D F K R S T Y S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P90866 588 67767 Y309 F P N S L H R Y F D K W K I N
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84TI6 470 52779 L294 H K Y D S V G L H N V V H L N
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 89.6 N.A. 99.5 N.A. 98.9 26.5 N.A. 99.3 99.1 87 95.6 N.A. 71.1 N.A. 47.1 N.A.
Protein Similarity: 100 89.6 N.A. 99.5 N.A. 99.1 42.4 N.A. 99.3 99.5 88.7 97.4 N.A. 77.8 N.A. 60.2 N.A.
P-Site Identity: 100 13.3 N.A. 100 N.A. 100 0 N.A. 100 100 13.3 100 N.A. 13.3 N.A. 33.3 N.A.
P-Site Similarity: 100 13.3 N.A. 100 N.A. 100 20 N.A. 100 100 13.3 100 N.A. 40 N.A. 53.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 38.5 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 55.1 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % A
% Cys: 0 0 50 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 9 0 9 0 0 0 9 0 9 17 0 0 0 0 % D
% Glu: 9 0 0 17 0 0 0 0 0 50 0 0 0 0 9 % E
% Phe: 9 0 0 0 0 0 0 0 17 0 0 0 0 0 17 % F
% Gly: 0 0 0 0 0 0 9 0 0 0 0 0 0 9 0 % G
% His: 9 9 9 0 0 25 0 0 9 0 0 50 9 0 0 % H
% Ile: 0 0 0 0 0 50 0 0 0 9 0 0 0 9 0 % I
% Lys: 17 9 0 9 17 0 75 0 17 9 59 0 75 0 50 % K
% Leu: 0 0 9 0 67 0 0 17 9 0 0 0 0 9 0 % L
% Met: 0 0 17 0 0 0 0 0 50 0 0 0 0 0 0 % M
% Asn: 0 50 9 0 0 0 9 0 0 9 9 0 9 0 17 % N
% Pro: 0 9 0 0 9 0 0 0 0 17 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % Q
% Arg: 9 0 0 0 0 0 9 0 0 0 9 9 0 0 0 % R
% Ser: 0 0 0 59 9 0 0 0 0 0 0 25 0 0 9 % S
% Thr: 50 0 0 9 0 9 0 0 0 0 0 0 9 9 0 % T
% Val: 0 0 0 0 0 9 0 17 0 0 9 9 0 50 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % W
% Tyr: 0 17 9 0 0 0 0 59 0 0 0 0 0 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _