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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK8
All Species:
32.73
Human Site:
Y422
Identified Species:
65.45
UniProt:
P49336
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49336
NP_001251.1
464
53284
Y422
G
L
I
M
T
S
D
Y
Q
R
S
N
P
H
A
Chimpanzee
Pan troglodytes
XP_001156631
416
47693
Y374
G
L
I
M
T
S
D
Y
Q
R
S
N
P
H
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_849851
463
53167
Y421
G
L
I
M
T
S
D
Y
Q
R
S
N
P
H
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8R3L8
464
53191
Y422
G
L
I
M
T
S
D
Y
Q
R
S
N
P
H
A
Rat
Rattus norvegicus
Q03114
292
33236
V251
A
T
T
S
L
V
N
V
V
P
K
L
N
A
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516816
464
53235
Y422
G
L
I
M
T
S
D
Y
Q
R
S
N
P
H
A
Chicken
Gallus gallus
XP_425638
464
53306
Y422
G
L
I
M
T
S
D
Y
Q
R
S
N
P
H
A
Frog
Xenopus laevis
Q66KH9
416
47745
Y374
G
L
I
M
T
S
D
Y
Q
R
S
N
P
H
A
Zebra Danio
Brachydanio rerio
Q8JH47
464
53215
Y422
G
L
I
M
T
S
D
Y
Q
R
S
N
P
H
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VT57
454
53663
R409
N
A
E
P
N
A
K
R
V
R
L
S
G
A
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P90866
588
67767
P487
G
R
Y
A
P
M
P
P
P
Y
G
A
P
Q
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q84TI6
470
52779
S414
N
M
Q
R
M
Q
Q
S
Q
G
M
M
A
Y
N
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
89.6
N.A.
99.5
N.A.
98.9
26.5
N.A.
99.3
99.1
87
95.6
N.A.
71.1
N.A.
47.1
N.A.
Protein Similarity:
100
89.6
N.A.
99.5
N.A.
99.1
42.4
N.A.
99.3
99.5
88.7
97.4
N.A.
77.8
N.A.
60.2
N.A.
P-Site Identity:
100
100
N.A.
100
N.A.
100
0
N.A.
100
100
100
100
N.A.
6.6
N.A.
13.3
N.A.
P-Site Similarity:
100
100
N.A.
100
N.A.
100
6.6
N.A.
100
100
100
100
N.A.
20
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
0
9
0
9
0
0
0
0
0
9
9
17
67
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
67
0
0
0
0
0
0
0
9
% D
% Glu:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
75
0
0
0
0
0
0
0
0
9
9
0
9
0
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
67
0
% H
% Ile:
0
0
67
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
9
0
0
0
9
0
0
0
0
% K
% Leu:
0
67
0
0
9
0
0
0
0
0
9
9
0
0
0
% L
% Met:
0
9
0
67
9
9
0
0
0
0
9
9
0
0
0
% M
% Asn:
17
0
0
0
9
0
9
0
0
0
0
67
9
0
9
% N
% Pro:
0
0
0
9
9
0
9
9
9
9
0
0
75
0
0
% P
% Gln:
0
0
9
0
0
9
9
0
75
0
0
0
0
9
0
% Q
% Arg:
0
9
0
9
0
0
0
9
0
75
0
0
0
0
0
% R
% Ser:
0
0
0
9
0
67
0
9
0
0
67
9
0
0
0
% S
% Thr:
0
9
9
0
67
0
0
0
0
0
0
0
0
0
9
% T
% Val:
0
0
0
0
0
9
0
9
17
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
9
0
0
0
0
67
0
9
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _