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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ALDH7A1 All Species: 2.73
Human Site: S30 Identified Species: 4.62
UniProt: P49419 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49419 NP_001173.2 539 58487 S30 _ _ _ _ _ _ M S T L L I N Q P
Chimpanzee Pan troglodytes XP_001157473 539 58521 S30 M S T L L I N Q P Q Y A W L K
Rhesus Macaque Macaca mulatta XP_001096223 539 58507 S30 M S T L L I N Q P Q Y A W L K
Dog Lupus familis XP_538607 539 58565 S30 M S T L L I N Q A Q Y A W L K
Cat Felis silvestris
Mouse Mus musculus Q9DBF1 539 58843 S30 M S T L L I H H P Q Y A W L Q
Rat Rattus norvegicus Q64057 539 58730 S30 M S T L L I H H P Q Y A W L Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505897 617 66249 A108 M A T L L I Q R P E Y G W L R
Chicken Gallus gallus O93344 518 56713 M20 L M A S L H L L P S P T L N L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_997889 511 55585 L14 W L K E L G L K E D N D G V Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_394614 527 56591 V16 M V R H L V T D P K Y G F L N
Nematode Worm Caenorhab. elegans P46562 531 56994 S20 A S Q L L I N D S K Y G F L K
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002331178 508 54809 S12 L S E I G L S S R N L G C Y V
Maize Zea mays NP_001149126 509 54399 A13 L A E L G L A Q R N P G A F A
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SYG7 508 54190 S12 L S E I G L T S H N L G S Y V
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 98.1 94.4 N.A. 88.3 88.8 N.A. 77.3 28.5 N.A. 80.1 N.A. N.A. 56.2 62.7 N.A.
Protein Similarity: 100 99.6 98.5 97 N.A. 94.2 94 N.A. 83.6 47.3 N.A. 88.5 N.A. N.A. 73.8 77.3 N.A.
P-Site Identity: 100 0 0 0 N.A. 0 0 N.A. 0 0 N.A. 0 N.A. N.A. 0 0 N.A.
P-Site Similarity: 100 6.6 6.6 6.6 N.A. 6.6 6.6 N.A. 6.6 6.6 N.A. 13.3 N.A. N.A. 0 13.3 N.A.
Percent
Protein Identity: 56 56.2 N.A. 56.7 N.A. N.A.
Protein Similarity: 70.8 69.7 N.A. 71.8 N.A. N.A.
P-Site Identity: 13.3 0 N.A. 13.3 N.A. N.A.
P-Site Similarity: 26.6 6.6 N.A. 33.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 15 8 0 0 0 8 0 8 0 0 36 8 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % C
% Asp: 0 0 0 0 0 0 0 15 0 8 0 8 0 0 0 % D
% Glu: 0 0 22 8 0 0 0 0 8 8 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 15 8 0 % F
% Gly: 0 0 0 0 22 8 0 0 0 0 0 43 8 0 0 % G
% His: 0 0 0 8 0 8 15 15 8 0 0 0 0 0 0 % H
% Ile: 0 0 0 15 0 50 0 0 0 0 0 8 0 0 0 % I
% Lys: 0 0 8 0 0 0 0 8 0 15 0 0 0 0 29 % K
% Leu: 29 8 0 58 72 22 15 8 0 8 22 0 8 58 8 % L
% Met: 50 8 0 0 0 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 29 0 0 22 8 0 8 8 8 % N
% Pro: 0 0 0 0 0 0 0 0 50 0 15 0 0 0 8 % P
% Gln: 0 0 8 0 0 0 8 29 0 36 0 0 0 8 15 % Q
% Arg: 0 0 8 0 0 0 0 8 15 0 0 0 0 0 8 % R
% Ser: 0 58 0 8 0 0 8 22 8 8 0 0 8 0 0 % S
% Thr: 0 0 43 0 0 0 15 0 8 0 0 8 0 0 0 % T
% Val: 0 8 0 0 0 8 0 0 0 0 0 0 0 8 15 % V
% Trp: 8 0 0 0 0 0 0 0 0 0 0 0 43 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 58 0 0 15 8 % Y
% Spaces: 8 8 8 8 8 8 0 0 0 0 0 0 0 0 0 % _