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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CENPA All Species: 14.24
Human Site: S17 Identified Species: 22.38
UniProt: P49450 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49450 NP_001035891.1 140 15991 S17 P E A P R R R S P S P T P T P
Chimpanzee Pan troglodytes XP_515346 138 15774 S17 P E A P R R R S P S P T P G P
Rhesus Macaque Macaca mulatta XP_001087306 138 15765 S17 P E A P R R R S P S P T P G P
Dog Lupus familis XP_532899 135 15196 P17 P K R R P A S P A P S A P R R
Cat Felis silvestris
Mouse Mus musculus O35216 134 15491 P17 P R R R P S S P A P G P S R Q
Rat Rattus norvegicus P84245 136 15309 P17 K S T G G K A P R K Q L A T K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509693 121 13998 R21 T P S P R R R R Y R P G K Q V
Chicken Gallus gallus Q6XXM1 131 15224 A18 R R G R P P P A A P P P P P A
Frog Xenopus laevis Q569M3 150 17325 T26 V S P P L P T T S R T S P R R
Zebra Danio Brachydanio rerio Q803H4 145 16662 S19 P S T P R R R S P P A S L P P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P02299 136 15370 P17 K S T G G K A P R K Q L A T K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q10453 136 15323 P17 K S T G G K A P R K Q L A T K
Sea Urchin Strong. purpuratus P06352 136 15483 P17 K S T G G K A P R K Q L A T K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LR02 136 15384 P17 K S H G G K A P R T L L A T K
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7RXR3 155 17319 T23 K K A A A V P T P K A T P P G
Conservation
Percent
Protein Identity: 100 98.5 92.8 77.1 N.A. 70 45 N.A. 60 58.5 54.6 55.1 N.A. 44.2 N.A. 44.2 44.2
Protein Similarity: 100 98.5 93.5 83.5 N.A. 80.7 56.4 N.A. 72.8 71.4 67.3 64.8 N.A. 57.1 N.A. 56.4 57.1
P-Site Identity: 100 93.3 93.3 13.3 N.A. 6.6 6.6 N.A. 33.3 13.3 13.3 53.3 N.A. 6.6 N.A. 6.6 6.6
P-Site Similarity: 100 93.3 93.3 20 N.A. 6.6 13.3 N.A. 40 20 26.6 60 N.A. 13.3 N.A. 13.3 13.3
Percent
Protein Identity: N.A. N.A. N.A. 47.8 N.A. 47.7
Protein Similarity: N.A. N.A. N.A. 58.5 N.A. 61.9
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. 26.6
P-Site Similarity: N.A. N.A. N.A. 20 N.A. 40
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 27 7 7 7 34 7 20 0 14 7 34 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 20 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 7 34 34 0 0 0 0 0 7 7 0 14 7 % G
% His: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 40 14 0 0 0 34 0 0 0 34 0 0 7 0 34 % K
% Leu: 0 0 0 0 7 0 0 0 0 0 7 34 7 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 40 7 7 40 20 14 14 47 34 27 34 14 47 20 27 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 27 0 0 7 7 % Q
% Arg: 7 14 14 20 34 34 34 7 34 14 0 0 0 20 14 % R
% Ser: 0 47 7 0 0 7 14 27 7 20 7 14 7 0 0 % S
% Thr: 7 0 34 0 0 0 7 14 0 7 7 27 0 40 0 % T
% Val: 7 0 0 0 0 7 0 0 0 0 0 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _