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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CENPA All Species: 3.94
Human Site: S37 Identified Species: 6.19
UniProt: P49450 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.29
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49450 NP_001035891.1 140 15991 S37 G P S L G A S S H Q H S R R R
Chimpanzee Pan troglodytes XP_515346 138 15774 Q37 S L G A S S H Q H S R R R Q G
Rhesus Macaque Macaca mulatta XP_001087306 138 15765 Q37 S L G P S S R Q H G R R R Q A
Dog Lupus familis XP_532899 135 15196 S37 T S S R H P G S R K H L V M K
Cat Felis silvestris
Mouse Mus musculus O35216 134 15491 Q37 S Q T L R R R Q K F M W L K E
Rat Rattus norvegicus P84245 136 15309 K37 A P S T G G V K K P H R Y R P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509693 121 13998 L41 R L Q K S T N L L L R K T P F
Chicken Gallus gallus Q6XXM1 131 15224 A38 R Y R P G Q R A L R E I R R Y
Frog Xenopus laevis Q569M3 150 17325 S46 Q R R A S R A S P K K R F R P
Zebra Danio Brachydanio rerio Q803H4 145 16662 S39 T R R H S G P S G S S P R K K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P02299 136 15370 K37 A P A T G G V K K P H R Y R P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q10453 136 15323 K37 A P T T G G V K K P H R Y R P
Sea Urchin Strong. purpuratus P06352 136 15483 K37 A P A T G G V K K P H R Y R P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LR02 136 15384 K37 A P T T G G V K K P H R Y R P
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7RXR3 155 17319 D43 A S S V Q P G D P V P Q G K K
Conservation
Percent
Protein Identity: 100 98.5 92.8 77.1 N.A. 70 45 N.A. 60 58.5 54.6 55.1 N.A. 44.2 N.A. 44.2 44.2
Protein Similarity: 100 98.5 93.5 83.5 N.A. 80.7 56.4 N.A. 72.8 71.4 67.3 64.8 N.A. 57.1 N.A. 56.4 57.1
P-Site Identity: 100 13.3 13.3 20 N.A. 6.6 33.3 N.A. 0 20 13.3 13.3 N.A. 26.6 N.A. 26.6 26.6
P-Site Similarity: 100 26.6 26.6 33.3 N.A. 20 33.3 N.A. 6.6 33.3 26.6 26.6 N.A. 33.3 N.A. 33.3 33.3
Percent
Protein Identity: N.A. N.A. N.A. 47.8 N.A. 47.7
Protein Similarity: N.A. N.A. N.A. 58.5 N.A. 61.9
P-Site Identity: N.A. N.A. N.A. 26.6 N.A. 6.6
P-Site Similarity: N.A. N.A. N.A. 33.3 N.A. 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 40 0 14 14 0 7 7 7 0 0 0 0 0 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 7 % E
% Phe: 0 0 0 0 0 0 0 0 0 7 0 0 7 0 7 % F
% Gly: 7 0 14 0 47 40 14 0 7 7 0 0 7 0 7 % G
% His: 0 0 0 7 7 0 7 0 20 0 47 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % I
% Lys: 0 0 0 7 0 0 0 34 40 14 7 7 0 20 20 % K
% Leu: 0 20 0 14 0 0 0 7 14 7 0 7 7 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 7 0 0 7 0 % M
% Asn: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % N
% Pro: 0 40 0 14 0 14 7 0 14 34 7 7 0 7 40 % P
% Gln: 7 7 7 0 7 7 0 20 0 7 0 7 0 14 0 % Q
% Arg: 14 14 20 7 7 14 20 0 7 7 20 54 34 54 7 % R
% Ser: 20 14 27 0 34 14 7 27 0 14 7 7 0 0 0 % S
% Thr: 14 0 20 34 0 7 0 0 0 0 0 0 7 0 0 % T
% Val: 0 0 0 7 0 0 34 0 0 7 0 0 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % W
% Tyr: 0 7 0 0 0 0 0 0 0 0 0 0 34 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _