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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CENPA All Species: 33.64
Human Site: S57 Identified Species: 52.86
UniProt: P49450 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49450 NP_001035891.1 140 15991 S57 E I R K L Q K S T H L L I R K
Chimpanzee Pan troglodytes XP_515346 138 15774 L63 T H L L I R K L P F S R L A R
Rhesus Macaque Macaca mulatta XP_001087306 138 15765 Y63 T H L L I R K Y P F S R L A R
Dog Lupus familis XP_532899 135 15196 N60 T N L L L R K N P F S R L V R
Cat Felis silvestris
Mouse Mus musculus O35216 134 15491 P60 D L L F R K K P F S M V V R E
Rat Rattus norvegicus P84245 136 15309 S58 E I R R Y Q K S T E L L I R K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509693 121 13998 T60 R E V C L S Y T R G V D F R W
Chicken Gallus gallus Q6XXM1 131 15224 P57 A L L L R R Q P F A R V V R E
Frog Xenopus laevis Q569M3 150 17325 S67 E I R K Y Q K S T E L L I R K
Zebra Danio Brachydanio rerio Q803H4 145 16662 S65 E I R K Y Q K S T G L L L R K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P02299 136 15370 S58 E I R R Y Q K S T E L L I R K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q10453 136 15323 S58 E I R R Y Q K S T E L L I R K
Sea Urchin Strong. purpuratus P06352 136 15483 S58 E I R R Y Q K S T E L L I R K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LR02 136 15384 S58 E I R K Y Q K S T E L L I R K
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7RXR3 155 17319 T69 E I R N Y Q R T T D L L V A K
Conservation
Percent
Protein Identity: 100 98.5 92.8 77.1 N.A. 70 45 N.A. 60 58.5 54.6 55.1 N.A. 44.2 N.A. 44.2 44.2
Protein Similarity: 100 98.5 93.5 83.5 N.A. 80.7 56.4 N.A. 72.8 71.4 67.3 64.8 N.A. 57.1 N.A. 56.4 57.1
P-Site Identity: 100 6.6 6.6 13.3 N.A. 13.3 80 N.A. 13.3 6.6 86.6 80 N.A. 80 N.A. 80 80
P-Site Similarity: 100 33.3 33.3 40 N.A. 60 86.6 N.A. 26.6 46.6 86.6 86.6 N.A. 86.6 N.A. 86.6 86.6
Percent
Protein Identity: N.A. N.A. N.A. 47.8 N.A. 47.7
Protein Similarity: N.A. N.A. N.A. 58.5 N.A. 61.9
P-Site Identity: N.A. N.A. N.A. 86.6 N.A. 53.3
P-Site Similarity: N.A. N.A. N.A. 86.6 N.A. 73.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 0 0 0 0 0 7 0 0 0 20 0 % A
% Cys: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 0 0 0 0 0 0 0 7 0 7 0 0 0 % D
% Glu: 60 7 0 0 0 0 0 0 0 40 0 0 0 0 14 % E
% Phe: 0 0 0 7 0 0 0 0 14 20 0 0 7 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 14 0 0 0 0 0 % G
% His: 0 14 0 0 0 0 0 0 0 7 0 0 0 0 0 % H
% Ile: 0 60 0 0 14 0 0 0 0 0 0 0 47 0 0 % I
% Lys: 0 0 0 27 0 7 80 0 0 0 0 0 0 0 60 % K
% Leu: 0 14 34 27 20 0 0 7 0 0 60 60 27 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % M
% Asn: 0 7 0 7 0 0 0 7 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 14 20 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 60 7 0 0 0 0 0 0 0 0 % Q
% Arg: 7 0 60 27 14 27 7 0 7 0 7 20 0 74 20 % R
% Ser: 0 0 0 0 0 7 0 54 0 7 20 0 0 0 0 % S
% Thr: 20 0 0 0 0 0 0 14 60 0 0 0 0 0 0 % T
% Val: 0 0 7 0 0 0 0 0 0 0 7 14 20 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % W
% Tyr: 0 0 0 0 54 0 7 7 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _