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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCYT1A All Species: 20.91
Human Site: S343 Identified Species: 32.86
UniProt: P49585 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49585 NP_005008.2 367 41731 S343 W P F S G K T S P P C S P A N
Chimpanzee Pan troglodytes XP_001143741 320 37092 S297 S R M L Q A L S P K Q S P L K
Rhesus Macaque Macaca mulatta XP_001090055 338 38695 L315 T S A S I R V L H V A S H H P
Dog Lupus familis XP_535776 367 41764 S343 W P F S G K T S P P S S P A N
Cat Felis silvestris
Mouse Mus musculus P49586 367 41648 S343 W P F S G K T S P S S S P A S
Rat Rattus norvegicus P19836 367 41662 S343 W P F S G K T S P S S S P A S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517894 294 33692 S270 W P F S A K A S P P S S P A N
Chicken Gallus gallus XP_422725 367 42078 P343 W P F S T K T P P S S P A N R
Frog Xenopus laevis NP_001089299 367 41920 S343 W P F S A K I S P P A S P G R
Zebra Danio Brachydanio rerio NP_001018571 359 41135 L334 P P S P S F R L P F F T S S P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_647621 526 58183 L461 S E T I D E Y L E M A E K L S
Honey Bee Apis mellifera XP_395764 403 46370 P373 E D Q T S P P P K K T G R F E
Nematode Worm Caenorhab. elegans P49583 362 41751 E333 E E E A L E E E K V V E Q K I
Sea Urchin Strong. purpuratus XP_001180754 425 48260 K363 G D S E E E Y K Y G L G Q A S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P13259 424 49388 S382 E D D E D T N S N N T N T N S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 58.5 60.7 96.4 N.A. 96.1 96.4 N.A. 77.3 89 86.3 76.2 N.A. 36.1 46.4 37.8 45.4
Protein Similarity: 100 69.2 71.6 98 N.A. 97.5 97.2 N.A. 78.1 95 91.2 84.1 N.A. 46 62 52.3 60
P-Site Identity: 100 26.6 13.3 93.3 N.A. 80 80 N.A. 80 46.6 66.6 13.3 N.A. 0 0 0 6.6
P-Site Similarity: 100 26.6 20 93.3 N.A. 86.6 86.6 N.A. 80 46.6 66.6 26.6 N.A. 13.3 6.6 13.3 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 34.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 50.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 7 14 7 7 0 0 0 20 0 7 40 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % C
% Asp: 0 20 7 0 14 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 20 14 7 14 7 20 7 7 7 0 0 14 0 0 7 % E
% Phe: 0 0 47 0 0 7 0 0 0 7 7 0 0 7 0 % F
% Gly: 7 0 0 0 27 0 0 0 0 7 0 14 0 7 0 % G
% His: 0 0 0 0 0 0 0 0 7 0 0 0 7 7 0 % H
% Ile: 0 0 0 7 7 0 7 0 0 0 0 0 0 0 7 % I
% Lys: 0 0 0 0 0 47 0 7 14 14 0 0 7 7 7 % K
% Leu: 0 0 0 7 7 0 7 20 0 0 7 0 0 14 0 % L
% Met: 0 0 7 0 0 0 0 0 0 7 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 7 0 7 7 0 7 0 14 20 % N
% Pro: 7 54 0 7 0 7 7 14 60 27 0 7 47 0 14 % P
% Gln: 0 0 7 0 7 0 0 0 0 0 7 0 14 0 0 % Q
% Arg: 0 7 0 0 0 7 7 0 0 0 0 0 7 0 14 % R
% Ser: 14 7 14 54 14 0 0 54 0 20 34 54 7 7 34 % S
% Thr: 7 0 7 7 7 7 34 0 0 0 14 7 7 0 0 % T
% Val: 0 0 0 0 0 0 7 0 0 14 7 0 0 0 0 % V
% Trp: 47 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 14 0 7 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _