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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CARS All Species: 38.18
Human Site: T637 Identified Species: 70
UniProt: P49589 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49589 NP_001742.1 748 85473 T637 E D H E G L P T V V K L V D R
Chimpanzee Pan troglodytes XP_001156397 748 85488 T637 E D H E G L P T V V K L V D R
Rhesus Macaque Macaca mulatta XP_001096538 748 85443 T637 E D H E G L P T V V K L V D R
Dog Lupus familis XP_533205 748 85441 T637 E D H E G L P T V V K L G D R
Cat Felis silvestris
Mouse Mus musculus Q9ER72 831 94841 T720 E D H E G L P T V V K L V D R
Rat Rattus norvegicus NP_001099789 748 85576 T637 E D H E G L P T V V K L V D R
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5F408 748 85783 T637 E D H E G L P T V V K L V D K
Frog Xenopus laevis Q7ZWR2 747 85766 T636 E D H E G L P T V V K L V D R
Zebra Danio Brachydanio rerio NP_001112372 824 93793 T715 E D R D G L P T S V K L V D K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KN90 741 84240 Y633 E D K D I G K Y A V K L V D R
Honey Bee Apis mellifera XP_394641 729 84971 C624 E D S N N E I C K I K L V N R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001195853 694 79206 P613 A L R D E V L P D L G V R L E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53852 767 87512 A659 D D R N G Q S A L I K F L T N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 97.4 88.9 N.A. 81.5 89.7 N.A. N.A. 81.9 76.4 69.9 N.A. 58.9 56.8 N.A. 56.8
Protein Similarity: 100 100 99 94.7 N.A. 87.2 96.1 N.A. N.A. 91.4 86 78.2 N.A. 71.6 71.9 N.A. 72
P-Site Identity: 100 100 100 93.3 N.A. 100 100 N.A. N.A. 93.3 100 73.3 N.A. 53.3 40 N.A. 0
P-Site Similarity: 100 100 100 93.3 N.A. 100 100 N.A. N.A. 100 100 86.6 N.A. 60 53.3 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 44.9 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 62 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 0 0 8 8 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 8 93 0 24 0 0 0 0 8 0 0 0 0 77 0 % D
% Glu: 85 0 0 62 8 8 0 0 0 0 0 0 0 0 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % F
% Gly: 0 0 0 0 77 8 0 0 0 0 8 0 8 0 0 % G
% His: 0 0 62 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 0 8 0 0 16 0 0 0 0 0 % I
% Lys: 0 0 8 0 0 0 8 0 8 0 93 0 0 0 16 % K
% Leu: 0 8 0 0 0 70 8 0 8 8 0 85 8 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 16 8 0 0 0 0 0 0 0 0 8 8 % N
% Pro: 0 0 0 0 0 0 70 8 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 24 0 0 0 0 0 0 0 0 0 8 0 70 % R
% Ser: 0 0 8 0 0 0 8 0 8 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 70 0 0 0 0 0 8 0 % T
% Val: 0 0 0 0 0 8 0 0 62 77 0 8 77 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _