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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRIM1 All Species: 8.79
Human Site: S319 Identified Species: 21.48
UniProt: P49642 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49642 NP_000937.1 420 49902 S319 G I N H L L K S P F S V H P K
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_849151 319 37820 I219 V S K S I N I I K K Y F E E Y
Cat Felis silvestris
Mouse Mus musculus P20664 417 49277 L316 S K G V N H L L K S P F S V H
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001080819 420 48972 S318 G L N H L L K S P F S V H P K
Zebra Danio Brachydanio rerio NP_958856 425 49707 F321 N H L L K S P F S V H P K T G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24317 438 50203 V337 Y P R L D I N V T R G F N H L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34471 410 48078 C310 L Y F V L Q R C Y P R L D V N
Sea Urchin Strong. purpuratus XP_791278 429 49651 S328 G V N H L L K S P F C V H P K
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001143441 453 51974 H348 L D M E V S K H M N H L L K A
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P10363 409 47672 L309 E D L V L M T L Y P K L D V E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 70.4 N.A. 90.4 N.A. N.A. N.A. N.A. 70.9 67.2 N.A. 41.3 N.A. 39 57.8
Protein Similarity: 100 N.A. N.A. 72.8 N.A. 95 N.A. N.A. N.A. N.A. 85 83 N.A. 59.5 N.A. 59.7 74.1
P-Site Identity: 100 N.A. N.A. 0 N.A. 0 N.A. N.A. N.A. N.A. 93.3 0 N.A. 0 N.A. 6.6 86.6
P-Site Similarity: 100 N.A. N.A. 6.6 N.A. 0 N.A. N.A. N.A. N.A. 100 0 N.A. 13.3 N.A. 20 93.3
Percent
Protein Identity: N.A. 40.1 N.A. N.A. 32.1 N.A.
Protein Similarity: N.A. 60.2 N.A. N.A. 55.4 N.A.
P-Site Identity: N.A. 6.6 N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. 20 N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % A
% Cys: 0 0 0 0 0 0 0 10 0 0 10 0 0 0 0 % C
% Asp: 0 20 0 0 10 0 0 0 0 0 0 0 20 0 0 % D
% Glu: 10 0 0 10 0 0 0 0 0 0 0 0 10 10 10 % E
% Phe: 0 0 10 0 0 0 0 10 0 30 0 30 0 0 0 % F
% Gly: 30 0 10 0 0 0 0 0 0 0 10 0 0 0 10 % G
% His: 0 10 0 30 0 10 0 10 0 0 20 0 30 10 10 % H
% Ile: 0 10 0 0 10 10 10 10 0 0 0 0 0 0 0 % I
% Lys: 0 10 10 0 10 0 40 0 20 10 10 0 10 10 30 % K
% Leu: 20 10 20 20 50 30 10 20 0 0 0 30 10 0 10 % L
% Met: 0 0 10 0 0 10 0 0 10 0 0 0 0 0 0 % M
% Asn: 10 0 30 0 10 10 10 0 0 10 0 0 10 0 10 % N
% Pro: 0 10 0 0 0 0 10 0 30 20 10 10 0 30 0 % P
% Gln: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 10 0 0 0 10 0 0 10 10 0 0 0 0 % R
% Ser: 10 10 0 10 0 20 0 30 10 10 20 0 10 0 0 % S
% Thr: 0 0 0 0 0 0 10 0 10 0 0 0 0 10 0 % T
% Val: 10 10 0 30 10 0 0 10 0 10 0 30 0 30 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 10 10 0 0 0 0 0 0 20 0 10 0 0 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _