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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRIM2 All Species: 18.79
Human Site: Y381 Identified Species: 29.52
UniProt: P49643 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49643 NP_000938.2 509 58806 Y381 N P P S Q G D Y H G C P F R H
Chimpanzee Pan troglodytes XP_001147112 340 39704 I217 P L K D I V A I I L N E F R A
Rhesus Macaque Macaca mulatta XP_001110968 509 58730 Y381 N P P S Q G D Y H G C P F R H
Dog Lupus familis XP_532185 509 58738 Y383 N P P G Q G D Y H G C P F R H
Cat Felis silvestris
Mouse Mus musculus P33610 505 58390 Y381 N P P G Q G D Y H G C P F R H
Rat Rattus norvegicus O89044 507 58584 F381 N P P S Q G D F H G C P F R H
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001012898 508 58704 Y381 N P P S Q G D Y H G C P F R H
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_999947 508 58723 D385 S N P P S Q G D Y H G C P F R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VPH2 533 61417 C390 D V A G P G D C H G C P Y K N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans O02334 503 58255 R380 M Y G K E G R R V A Q T A M S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002303780 453 52160 V330 K A E F S Q K V G A E R F D K
Maize Zea mays NP_001130651 458 52153 K335 I G S E R F D K E Y A Y S I R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84WJ2 454 52055 E331 F T K K V G S E R F D K E Y A
Baker's Yeast Sacchar. cerevisiae P20457 528 62244 Y403 R Y S F R H N Y G L E G N R I
Red Bread Mold Neurospora crassa Q8NIZ4 513 59504 R388 D V G G D S N R R G G G Y S P
Conservation
Percent
Protein Identity: 100 66.8 97 89.9 N.A. 89.3 88.4 N.A. N.A. 68.5 N.A. 66.2 N.A. 36.4 N.A. 40.4 N.A.
Protein Similarity: 100 66.8 98 94.8 N.A. 93.9 93.7 N.A. N.A. 82.5 N.A. 80.1 N.A. 57.9 N.A. 59.9 N.A.
P-Site Identity: 100 13.3 100 93.3 N.A. 93.3 93.3 N.A. N.A. 100 N.A. 6.6 N.A. 40 N.A. 6.6 N.A.
P-Site Similarity: 100 13.3 100 93.3 N.A. 93.3 100 N.A. N.A. 100 N.A. 20 N.A. 66.6 N.A. 13.3 N.A.
Percent
Protein Identity: 37.5 39.2 N.A. 38.7 32.5 35.4
Protein Similarity: 56.5 56.3 N.A. 56.1 52 53
P-Site Identity: 6.6 6.6 N.A. 6.6 13.3 6.6
P-Site Similarity: 6.6 13.3 N.A. 6.6 26.6 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 7 0 0 0 7 0 0 14 7 0 7 0 14 % A
% Cys: 0 0 0 0 0 0 0 7 0 0 47 7 0 0 0 % C
% Asp: 14 0 0 7 7 0 54 7 0 0 7 0 0 7 0 % D
% Glu: 0 0 7 7 7 0 0 7 7 0 14 7 7 0 0 % E
% Phe: 7 0 0 14 0 7 0 7 0 7 0 0 54 7 0 % F
% Gly: 0 7 14 27 0 60 7 0 14 54 14 14 0 0 0 % G
% His: 0 0 0 0 0 7 0 0 47 7 0 0 0 0 40 % H
% Ile: 7 0 0 0 7 0 0 7 7 0 0 0 0 7 7 % I
% Lys: 7 0 14 14 0 0 7 7 0 0 0 7 0 7 7 % K
% Leu: 0 7 0 0 0 0 0 0 0 14 0 0 0 0 0 % L
% Met: 7 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % M
% Asn: 40 7 0 0 0 0 14 0 0 0 7 0 7 0 7 % N
% Pro: 7 40 47 7 7 0 0 0 0 0 0 47 7 0 7 % P
% Gln: 0 0 0 0 40 14 0 0 0 0 7 0 0 0 0 % Q
% Arg: 7 0 0 0 14 0 7 14 14 0 0 7 0 54 14 % R
% Ser: 7 0 14 27 14 7 7 0 0 0 0 0 7 7 7 % S
% Thr: 0 7 0 0 0 0 0 0 0 0 0 7 0 0 0 % T
% Val: 0 14 0 0 7 7 0 7 7 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 14 0 0 0 0 0 40 7 7 0 7 14 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _